Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970786982> ?p ?o ?g. }
- W1970786982 endingPage "52" @default.
- W1970786982 startingPage "43" @default.
- W1970786982 abstract "Alpha-tocopheryl polyethylene glycol succinate (TPGS) has been used to enhance the bioavailability of poorly absorbed drugs and as a vehicle for drug delivery systems. In response to recent reports that alpha-tocopheryl succinate (TOS) acts as an anticancer agent, we investigated whether its polyethylene glycol (PEG) conjugate, TPGS, also possesses anticancer activity. TPGS inhibited the growth of human lung carcinoma cells implanted in nude mice, and in an in vitro cell culture, even more potently than TOS. The time-dependent uptake of TPGS into cells did not differ from that of TOS, indicating that the enhanced antitumor efficacy of TPGS was not due to its increased uptake into cells. Compared with TOS, TPGS was more effective at inducing apoptosis and the generation of reactive oxygen species, suggesting that the superior anticancer efficacy of TPGS is associated with its increased ability to induce apoptosis. Our data suggest that further studies assessing the potential usefulness of TPGS in cancer therapeutics are warranted, since its use as a vehicle in the formulation of anticancer drugs may provide an effective way to improve their therapeutic efficacy." @default.
- W1970786982 created "2016-06-24" @default.
- W1970786982 creator A5002821440 @default.
- W1970786982 creator A5019153344 @default.
- W1970786982 creator A5026694504 @default.
- W1970786982 creator A5035039429 @default.
- W1970786982 creator A5035117454 @default.
- W1970786982 creator A5055620404 @default.
- W1970786982 creator A5069788903 @default.
- W1970786982 creator A5087132038 @default.
- W1970786982 date "2005-09-20" @default.
- W1970786982 modified "2023-10-03" @default.
- W1970786982 title "Enhanced anticancer efficacy of α-tocopheryl succinate by conjugation with polyethylene glycol" @default.
- W1970786982 cites W1545412451 @default.
- W1970786982 cites W1876282953 @default.
- W1970786982 cites W1975009275 @default.
- W1970786982 cites W1977915398 @default.
- W1970786982 cites W1980523048 @default.
- W1970786982 cites W1987711340 @default.
- W1970786982 cites W1994603883 @default.
- W1970786982 cites W1997871823 @default.
- W1970786982 cites W1999314540 @default.
- W1970786982 cites W2001071264 @default.
- W1970786982 cites W2005464759 @default.
- W1970786982 cites W2011370547 @default.
- W1970786982 cites W2013168057 @default.
- W1970786982 cites W2021693564 @default.
- W1970786982 cites W2031104374 @default.
- W1970786982 cites W2036650324 @default.
- W1970786982 cites W2037485696 @default.
- W1970786982 cites W2041149058 @default.
- W1970786982 cites W2043287922 @default.
- W1970786982 cites W2055832389 @default.
- W1970786982 cites W2056112148 @default.
- W1970786982 cites W2056961821 @default.
- W1970786982 cites W2061670194 @default.
- W1970786982 cites W2062519920 @default.
- W1970786982 cites W2075469401 @default.
- W1970786982 cites W2079540810 @default.
- W1970786982 cites W2081695376 @default.
- W1970786982 cites W2082828565 @default.
- W1970786982 cites W2085635460 @default.
- W1970786982 cites W2099314766 @default.
- W1970786982 cites W2100914972 @default.
- W1970786982 cites W2108397865 @default.
- W1970786982 cites W2137307414 @default.
- W1970786982 cites W2421798224 @default.
- W1970786982 cites W307925432 @default.
- W1970786982 cites W66407225 @default.
- W1970786982 doi "https://doi.org/10.1016/j.jconrel.2005.05.014" @default.
- W1970786982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16081183" @default.
- W1970786982 hasPublicationYear "2005" @default.
- W1970786982 type Work @default.
- W1970786982 sameAs 1970786982 @default.
- W1970786982 citedByCount "155" @default.
- W1970786982 countsByYear W19707869822012 @default.
- W1970786982 countsByYear W19707869822013 @default.
- W1970786982 countsByYear W19707869822014 @default.
- W1970786982 countsByYear W19707869822015 @default.
- W1970786982 countsByYear W19707869822016 @default.
- W1970786982 countsByYear W19707869822017 @default.
- W1970786982 countsByYear W19707869822018 @default.
- W1970786982 countsByYear W19707869822019 @default.
- W1970786982 countsByYear W19707869822020 @default.
- W1970786982 countsByYear W19707869822021 @default.
- W1970786982 countsByYear W19707869822022 @default.
- W1970786982 countsByYear W19707869822023 @default.
- W1970786982 crossrefType "journal-article" @default.
- W1970786982 hasAuthorship W1970786982A5002821440 @default.
- W1970786982 hasAuthorship W1970786982A5019153344 @default.
- W1970786982 hasAuthorship W1970786982A5026694504 @default.
- W1970786982 hasAuthorship W1970786982A5035039429 @default.
- W1970786982 hasAuthorship W1970786982A5035117454 @default.
- W1970786982 hasAuthorship W1970786982A5055620404 @default.
- W1970786982 hasAuthorship W1970786982A5069788903 @default.
- W1970786982 hasAuthorship W1970786982A5087132038 @default.
- W1970786982 hasConcept C10138342 @default.
- W1970786982 hasConcept C162324750 @default.
- W1970786982 hasConcept C178790620 @default.
- W1970786982 hasConcept C181389837 @default.
- W1970786982 hasConcept C185592680 @default.
- W1970786982 hasConcept C190283241 @default.
- W1970786982 hasConcept C202751555 @default.
- W1970786982 hasConcept C2776964284 @default.
- W1970786982 hasConcept C2779149719 @default.
- W1970786982 hasConcept C2779820397 @default.
- W1970786982 hasConcept C48349386 @default.
- W1970786982 hasConcept C54400483 @default.
- W1970786982 hasConcept C55493867 @default.
- W1970786982 hasConcept C71924100 @default.
- W1970786982 hasConcept C98274493 @default.
- W1970786982 hasConceptScore W1970786982C10138342 @default.
- W1970786982 hasConceptScore W1970786982C162324750 @default.
- W1970786982 hasConceptScore W1970786982C178790620 @default.
- W1970786982 hasConceptScore W1970786982C181389837 @default.
- W1970786982 hasConceptScore W1970786982C185592680 @default.
- W1970786982 hasConceptScore W1970786982C190283241 @default.
- W1970786982 hasConceptScore W1970786982C202751555 @default.