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• W1970789977 endingPage "426" @default.
• W1970789977 startingPage "369" @default.
• W1970789977 abstract "To interpret the growing body of data describing the structural, physical, and chemical behaviors of biological macromolecules, some understanding must be developed to relate these behaviors to the evolutionary processes that created them. Behaviors that are the products of natural selection reflect biological function and offer clues to the underlying chemical principles. Nonselected behaviors reflect historical accident and random drift. This review considers experimental data relevant to distinguishing between nonfunctional and functional behaviors in biological macromolecules. In the first segment, tools are developed for building functional and historical models to explain macromolecular behavior. These tools are then used with recent experimental data to develop a general outline of the relationship between structure, behavior, and natural selection in proteins and nucleic acids. In segments published elsewhere, specific functional and historical models for three properties of enzymes--kinetics, stereospecificity, and specificity for cofactor structures--are examined. Functional models appear most suitable for explaining the kinetic behavior of proteins. A mixture of functional and historical models appears necessary to understand the stereospecificity of enzyme reactions. Specificity for cofactor structures appears best understood in light of purely historical models based on a hypothesis of an early form of life exclusively using RNA catalysis." @default.
• W1970789977 created "2016-06-24" @default.
• W1970789977 creator A5005259044 @default.
• W1970789977 creator A5089627980 @default.
• W1970789977 date "1988-01-01" @default.
• W1970789977 modified "2023-09-23" @default.
• W1970789977 title "Interpreting the Behavior of Enzymes Purpose or Pedigree?" @default.
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