FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970799984> ?p ?o ?g. }

• W1970799984 endingPage "772" @default.
• W1970799984 startingPage "765" @default.
• W1970799984 abstract "Sterol regulatory element–binding proteins (SREBPs) are transcription factors governing transcription of genes related to cholesterol and fatty acid metabolism. To become active, SREBPs must undergo a proteolytic cleavage to allow an active NH2-terminal segment to translocate into the nucleus. SKI-1/S1P is the first protease in the proteolytic activation cascade of SREBPs. SREBP inhibition may be useful, for example, in the treatment of liver steatosis caused by homocysteine-induced lipid synthesis. Accordingly, we overexpressed inhibitory prodomains (proSKI) of SKI-1/S1P in HepG2 cells to block SREBP activation to evaluate the potential of SKI-1/S1P in controlling cellular cholesterol synthesis. SKI-1/S1P inhibition resulted in reduced cholesterol synthesis and mRNA levels of the rate-limiting enzymes, HMG-CoA reductase and squalene epoxidase, in the cholesterol synthetic pathway. The inhibitory effect was maintained in the presence of homocysteine-induced endoplasmic reticulum stress. A gene set enrichment analysis was performed to elucidate other metabolic effects caused by SKI-1/S1P inhibition. SKI-1/S1P inhibition was observed to affect a number of other metabolic pathways, including glycolysis and citric acid cycle. These results demonstrate that inhibition of SREBPs decreases cholesterol synthesis in HepG2 cells both in the absence and presence of homocysteine. SKI-1/S1P inhibition may cause widespread changes in other key metabolic pathways." @default.
• W1970799984 created "2016-06-24" @default.
• W1970799984 creator A5000608187 @default.
• W1970799984 creator A5003724244 @default.
• W1970799984 creator A5011384937 @default.
• W1970799984 creator A5016693947 @default.
• W1970799984 creator A5061820384 @default.
• W1970799984 creator A5069910791 @default.
• W1970799984 creator A5070770963 @default.
• W1970799984 creator A5070875834 @default.
• W1970799984 creator A5071412244 @default.
• W1970799984 creator A5071534616 @default.
• W1970799984 creator A5073873243 @default.
• W1970799984 creator A5080418392 @default.
• W1970799984 creator A5080860690 @default.
• W1970799984 creator A5082034293 @default.
• W1970799984 creator A5088163819 @default.
• W1970799984 creator A5090995081 @default.
• W1970799984 date "2007-11-01" @default.
• W1970799984 modified "2023-10-17" @default.
• W1970799984 title "Gene Set Enrichment Analysis Reveals Several Globally Affected Pathways due to SKI-1/S1P Inhibition in HepG2 Cells" @default.
• W1970799984 cites W1523134239 @default.
• W1970799984 cites W1748636648 @default.
• W1970799984 cites W1966350789 @default.
• W1970799984 cites W1968953041 @default.
• W1970799984 cites W1972561828 @default.
• W1970799984 cites W1983003002 @default.
• W1970799984 cites W1983469573 @default.
• W1970799984 cites W1997329503 @default.
• W1970799984 cites W1997613978 @default.
• W1970799984 cites W2004168108 @default.
• W1970799984 cites W2004454505 @default.
• W1970799984 cites W2022538200 @default.
• W1970799984 cites W2023719883 @default.
• W1970799984 cites W2024851295 @default.
• W1970799984 cites W2027486144 @default.
• W1970799984 cites W2029753295 @default.
• W1970799984 cites W2031889049 @default.
• W1970799984 cites W2035225324 @default.
• W1970799984 cites W2037254183 @default.
• W1970799984 cites W2043973752 @default.
• W1970799984 cites W2045700225 @default.
• W1970799984 cites W2046422846 @default.
• W1970799984 cites W2073926725 @default.
• W1970799984 cites W2075165730 @default.
• W1970799984 cites W2080868127 @default.
• W1970799984 cites W2080960170 @default.
• W1970799984 cites W2084212236 @default.
• W1970799984 cites W2084342216 @default.
• W1970799984 cites W2090253176 @default.
• W1970799984 cites W2094998344 @default.
• W1970799984 cites W2095615927 @default.
• W1970799984 cites W2099765629 @default.
• W1970799984 cites W2099765837 @default.
• W1970799984 cites W2114472618 @default.
• W1970799984 cites W2121255486 @default.
• W1970799984 cites W2122391469 @default.
• W1970799984 cites W2130410032 @default.
• W1970799984 cites W2135007868 @default.
• W1970799984 cites W2142137533 @default.
• W1970799984 cites W2146544786 @default.
• W1970799984 cites W2398798350 @default.
• W1970799984 doi "https://doi.org/10.1089/dna.2007.0624" @default.
• W1970799984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17867930" @default.
• W1970799984 hasPublicationYear "2007" @default.
• W1970799984 type Work @default.
• W1970799984 sameAs 1970799984 @default.
• W1970799984 citedByCount "9" @default.
• W1970799984 countsByYear W19707999842012 @default.
• W1970799984 countsByYear W19707999842013 @default.
• W1970799984 countsByYear W19707999842015 @default.
• W1970799984 countsByYear W19707999842020 @default.
• W1970799984 crossrefType "journal-article" @default.
• W1970799984 hasAuthorship W1970799984A5000608187 @default.
• W1970799984 hasAuthorship W1970799984A5003724244 @default.
• W1970799984 hasAuthorship W1970799984A5011384937 @default.
• W1970799984 hasAuthorship W1970799984A5016693947 @default.
• W1970799984 hasAuthorship W1970799984A5061820384 @default.
• W1970799984 hasAuthorship W1970799984A5069910791 @default.
• W1970799984 hasAuthorship W1970799984A5070770963 @default.
• W1970799984 hasAuthorship W1970799984A5070875834 @default.
• W1970799984 hasAuthorship W1970799984A5071412244 @default.
• W1970799984 hasAuthorship W1970799984A5071534616 @default.
• W1970799984 hasAuthorship W1970799984A5073873243 @default.
• W1970799984 hasAuthorship W1970799984A5080418392 @default.
• W1970799984 hasAuthorship W1970799984A5080860690 @default.
• W1970799984 hasAuthorship W1970799984A5082034293 @default.
• W1970799984 hasAuthorship W1970799984A5088163819 @default.
• W1970799984 hasAuthorship W1970799984A5090995081 @default.
• W1970799984 hasConcept C104317684 @default.
• W1970799984 hasConcept C134651460 @default.
• W1970799984 hasConcept C181199279 @default.
• W1970799984 hasConcept C2776941171 @default.
• W1970799984 hasConcept C2779123261 @default.
• W1970799984 hasConcept C55493867 @default.
• W1970799984 hasConcept C85051948 @default.
• W1970799984 hasConcept C86339819 @default.
• W1970799984 hasConcept C86803240 @default.

• next