FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970803647> ?p ?o ?g. }

• W1970803647 abstract "The hyperthermia as well as radiation responses of multidrug resistant (CEM/VLB100 with classical MDR and CEM/VM-1 with atypical MDR), methotrexate resistant (CEM/MTX) subclones of CCRF-CEM T-lineage ALL cell line were compared with those of a drug sensitive (CEM-1-3) subclone from the same parent cell line. Also analyzed were the hyperthermia as well as radiation responses of multidrug resistant (HL60/AR) and drug sensitive subclones of the HL60 AML cell line. Notably, the drug resistant subclones of CEM and HL60 were as sensitive to hyperthermia as were the drug sensitive subclones. Importantly, no thermotolerant plateau was observed in the hyperthermia survival curves of the drug resistant subclones, indicating that drug/multidrug resistance is not associated with a greater likelihood of thermal tolerance development during hyperthermia. Similarly, the drug resistant CEM and HL60 subclones were not more radiation resistant than the drug sensitive subclones. Thus, the classical or atypical forms of multidrug resistance or methotrexate resistance of the analyzed leukemic cell lines were not associated with radiation resistance. Furthermore, the radiation survival curves of the drug resistant subclones lacked a distinct initial shoulder and their n values were not greater than those of the drug sensitive subclones, suggesting that multidrug resistance is not associated with an increased ability to repair or accumulate sublethal radiation damage. Our findings provide evidence that there is no apparent association between drug/multidrug resistance and heat or radiation sensitivity of CEM T-lineage ALL or HL60 AML leukemia cells. The results of this study indicate that acquired resistance to methotrexate, vinblastine, vincristine, etoposide, actinomycin-D, adriamycin, or daunomycin, or pleiotropic multidrug resistance do not necessarily confer radiation resistance for human leukemic cells." @default.
• W1970803647 created "2016-06-24" @default.
• W1970803647 creator A5016850978 @default.
• W1970803647 creator A5033214055 @default.
• W1970803647 creator A5035874193 @default.
• W1970803647 creator A5051714527 @default.
• W1970803647 creator A5060239856 @default.
• W1970803647 creator A5072939048 @default.
• W1970803647 creator A5091381226 @default.
• W1970803647 date "1992-01-01" @default.
• W1970803647 modified "2023-09-26" @default.
• W1970803647 title "Radiation and heat sensitivity of human T-lineage acute lymphoblastic leukemia (ALL) and acute myeloblastic leukemia (AML) clones displaying multiple drug resistance (MDR)" @default.
• W1970803647 cites W1490843783 @default.
• W1970803647 cites W1498463354 @default.
• W1970803647 cites W1499822007 @default.
• W1970803647 cites W1503202313 @default.
• W1970803647 cites W1531372132 @default.
• W1970803647 cites W1532947306 @default.
• W1970803647 cites W1536923222 @default.
• W1970803647 cites W1564690801 @default.
• W1970803647 cites W1571107804 @default.
• W1970803647 cites W1654332317 @default.
• W1970803647 cites W1655328368 @default.
• W1970803647 cites W1796027951 @default.
• W1970803647 cites W1924125329 @default.
• W1970803647 cites W1930162478 @default.
• W1970803647 cites W1988122705 @default.
• W1970803647 cites W1990675723 @default.
• W1970803647 cites W2004581336 @default.
• W1970803647 cites W2007064404 @default.
• W1970803647 cites W2010203433 @default.
• W1970803647 cites W2013351985 @default.
• W1970803647 cites W2017165269 @default.
• W1970803647 cites W2028651992 @default.
• W1970803647 cites W2041456649 @default.
• W1970803647 cites W2053379947 @default.
• W1970803647 cites W2065973867 @default.
• W1970803647 cites W2100341370 @default.
• W1970803647 cites W2116051303 @default.
• W1970803647 cites W2141567844 @default.
• W1970803647 cites W2153471759 @default.
• W1970803647 cites W2154110599 @default.
• W1970803647 cites W2168310623 @default.
• W1970803647 cites W2168793395 @default.
• W1970803647 cites W2168885796 @default.
• W1970803647 cites W2169950926 @default.
• W1970803647 cites W2262616213 @default.
• W1970803647 cites W2325461696 @default.
• W1970803647 cites W2330491673 @default.
• W1970803647 cites W2337104376 @default.
• W1970803647 cites W233960 @default.
• W1970803647 cites W2408069820 @default.
• W1970803647 cites W2414185176 @default.
• W1970803647 cites W2414479209 @default.
• W1970803647 cites W2416339276 @default.
• W1970803647 cites W2442391142 @default.
• W1970803647 cites W2444049942 @default.
• W1970803647 cites W2472832889 @default.
• W1970803647 cites W2615953705 @default.
• W1970803647 cites W1860172163 @default.
• W1970803647 cites W2145909401 @default.
• W1970803647 doi "https://doi.org/10.1016/0360-3016(92)90550-2" @default.
• W1970803647 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1572809" @default.
• W1970803647 hasPublicationYear "1992" @default.
• W1970803647 type Work @default.
• W1970803647 sameAs 1970803647 @default.
• W1970803647 citedByCount "9" @default.
• W1970803647 countsByYear W19708036472013 @default.
• W1970803647 crossrefType "journal-article" @default.
• W1970803647 hasAuthorship W1970803647A5016850978 @default.
• W1970803647 hasAuthorship W1970803647A5033214055 @default.
• W1970803647 hasAuthorship W1970803647A5035874193 @default.
• W1970803647 hasAuthorship W1970803647A5051714527 @default.
• W1970803647 hasAuthorship W1970803647A5060239856 @default.
• W1970803647 hasAuthorship W1970803647A5072939048 @default.
• W1970803647 hasAuthorship W1970803647A5091381226 @default.
• W1970803647 hasConcept C111337013 @default.
• W1970803647 hasConcept C114851261 @default.
• W1970803647 hasConcept C121332964 @default.
• W1970803647 hasConcept C126322002 @default.
• W1970803647 hasConcept C133936738 @default.
• W1970803647 hasConcept C185544564 @default.
• W1970803647 hasConcept C203014093 @default.
• W1970803647 hasConcept C26114605 @default.
• W1970803647 hasConcept C2778461978 @default.
• W1970803647 hasConcept C2778729363 @default.
• W1970803647 hasConcept C2778903051 @default.
• W1970803647 hasConcept C2779378344 @default.
• W1970803647 hasConcept C2779949491 @default.
• W1970803647 hasConcept C2780035454 @default.
• W1970803647 hasConcept C502942594 @default.
• W1970803647 hasConcept C54355233 @default.
• W1970803647 hasConcept C71924100 @default.
• W1970803647 hasConcept C86803240 @default.
• W1970803647 hasConcept C98274493 @default.
• W1970803647 hasConceptScore W1970803647C111337013 @default.
• W1970803647 hasConceptScore W1970803647C114851261 @default.
• W1970803647 hasConceptScore W1970803647C121332964 @default.
• W1970803647 hasConceptScore W1970803647C126322002 @default.
• W1970803647 hasConceptScore W1970803647C133936738 @default.

• next