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- W1970809361 abstract "We have screened 78 genital tract tumours from Italian female patients for the presence of human papillomavirus type 16 (HPV-16) and HPV-18 DNA. Dot and Southern blot hybridization experiments revealed that DNA sequences of HPV-16 and/or HPV-18 are present in 66% of tumour samples. HPV-18 was detected in 80% of vulvar carcinomas. In these tumours the integration of HPV-18 DNA seems to occur in the E1/E2 region of the virus genome with long deletions in almost all samples. The invariable retention of the non-coding region and the E6/E7 open reading frames suggests that the integration event and the possible expression of these sequences could play a role in some stages of cellular transformation." @default.
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- W1970809361 date "1989-06-01" @default.
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- W1970809361 title "Presence of Human Papillomavirus Type 18 DNA in Vulvar Carcinomas and Its Integration into the Cell Genome" @default.
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- W1970809361 doi "https://doi.org/10.1099/0022-1317-70-6-1587" @default.
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