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• W1970812448 abstract "In the mammalian brain, glutamate and gamma-aminobutyric acid are considered major excitatory and inhibitory neurotransmitters, respectively. However, we have found evidence that glutamate can also act as a postsynaptic inhibitory neurotransmitter in layer 4 of the neocortex. Using whole-cell recordings from layer 4 neurons in slice preparations from the mouse visual, auditory, and somatosensory cortices, we found that metabotropic glutamate receptor (mGluR) agonists (ACPD, APDC, and DCG IV) elicit a robust, long-lasting hyperpolarization that is abolished by the group II mGluR antagonist, MCCG. This response largely involves a K(+) conductance mediated by G-protein activity and GIRK channels. Furthermore, electrical and photostimulation of the intracortical inputs to layer 4 elicits a similar hyperpolarization that is blocked by group II mGluR antagonists. This novel inhibition mediated by group II mGluRs may be an unappreciated mechanism for refining cortical receptive fields in layer 4 and may enable synaptic gain control during periods of high activity." @default.
• W1970812448 created "2016-06-24" @default.
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• W1970812448 date "2009-01-28" @default.
• W1970812448 modified "2023-10-13" @default.
• W1970812448 title "Glutamatergic Inhibition in Sensory Neocortex" @default.
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• W1970812448 doi "https://doi.org/10.1093/cercor/bhn246" @default.
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