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- W1970826261 endingPage "1315" @default.
- W1970826261 startingPage "1289" @default.
- W1970826261 abstract "Ubiquitylation is a major posttranslational modification that controls most complex aspects of cell physiology. It is reversed through the action of a large family of deubiquitylating enzymes (DUBs) that are emerging as attractive therapeutic targets for a number of disease conditions. Here, we provide a comprehensive analysis of the complement of human DUBs, indicating structural motifs, typical cellular copy numbers, and tissue expression profiles. We discuss the means by which specificity is achieved and how DUB activity may be regulated. Generically DUB catalytic activity may be used to 1) maintain free ubiquitin levels, 2) rescue proteins from ubiquitin-mediated degradation, and 3) control the dynamics of ubiquitin-mediated signaling events. Functional roles of individual DUBs from each of five subfamilies in specific cellular processes are highlighted with an emphasis on those linked to pathological conditions where the association is supported by whole organism models. We then specifically consider the role of DUBs associated with protein degradative machineries and the influence of specific DUBs upon expression of receptors and channels at the plasma membrane." @default.
- W1970826261 created "2016-06-24" @default.
- W1970826261 creator A5009636964 @default.
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- W1970826261 creator A5040243630 @default.
- W1970826261 creator A5089277444 @default.
- W1970826261 creator A5091908521 @default.
- W1970826261 date "2013-07-01" @default.
- W1970826261 modified "2023-10-16" @default.
- W1970826261 title "Deubiquitylases From Genes to Organism" @default.
- W1970826261 cites W1511827873 @default.
- W1970826261 cites W1534406401 @default.
- W1970826261 cites W1541556706 @default.
- W1970826261 cites W1552171878 @default.
- W1970826261 cites W1564987250 @default.
- W1970826261 cites W1573247099 @default.
- W1970826261 cites W1577743463 @default.
- W1970826261 cites W1591200005 @default.
- W1970826261 cites W1618846043 @default.
- W1970826261 cites W1864085864 @default.
- W1970826261 cites W1936789375 @default.
- W1970826261 cites W1964365041 @default.
- W1970826261 cites W1966818689 @default.
- W1970826261 cites W1968055671 @default.
- W1970826261 cites W1968360648 @default.
- W1970826261 cites W1968492615 @default.
- W1970826261 cites W1969932442 @default.
- W1970826261 cites W1971792138 @default.
- W1970826261 cites W1972378799 @default.
- W1970826261 cites W1973743880 @default.
- W1970826261 cites W1978274009 @default.
- W1970826261 cites W1978720506 @default.
- W1970826261 cites W1979652500 @default.
- W1970826261 cites W1979873360 @default.
- W1970826261 cites W1980468156 @default.
- W1970826261 cites W1980667399 @default.
- W1970826261 cites W1982606786 @default.
- W1970826261 cites W1985469117 @default.
- W1970826261 cites W1986565958 @default.
- W1970826261 cites W1987871280 @default.
- W1970826261 cites W1988100248 @default.
- W1970826261 cites W1988291911 @default.
- W1970826261 cites W1988418980 @default.
- W1970826261 cites W1989561383 @default.
- W1970826261 cites W1990741894 @default.
- W1970826261 cites W1992174702 @default.
- W1970826261 cites W1992436832 @default.
- W1970826261 cites W1993416010 @default.
- W1970826261 cites W1994751787 @default.
- W1970826261 cites W1995068520 @default.
- W1970826261 cites W1995392239 @default.
- W1970826261 cites W1995747121 @default.
- W1970826261 cites W1997146393 @default.
- W1970826261 cites W1997180807 @default.
- W1970826261 cites W1998684648 @default.
- W1970826261 cites W1999289004 @default.
- W1970826261 cites W1999290683 @default.
- W1970826261 cites W2000017794 @default.
- W1970826261 cites W2000724093 @default.
- W1970826261 cites W2001234769 @default.
- W1970826261 cites W2001499126 @default.
- W1970826261 cites W2002877292 @default.
- W1970826261 cites W2006920169 @default.
- W1970826261 cites W2007160323 @default.
- W1970826261 cites W2007277647 @default.
- W1970826261 cites W2007541023 @default.
- W1970826261 cites W2007702034 @default.
- W1970826261 cites W2008207745 @default.
- W1970826261 cites W2009234149 @default.
- W1970826261 cites W2010315416 @default.
- W1970826261 cites W2011369317 @default.
- W1970826261 cites W2012296420 @default.
- W1970826261 cites W2012917547 @default.
- W1970826261 cites W2013057562 @default.
- W1970826261 cites W2013092025 @default.
- W1970826261 cites W2014630160 @default.
- W1970826261 cites W2015031034 @default.
- W1970826261 cites W2015788406 @default.
- W1970826261 cites W2016758355 @default.
- W1970826261 cites W2018915744 @default.
- W1970826261 cites W2019179677 @default.
- W1970826261 cites W2020288988 @default.
- W1970826261 cites W2020781390 @default.
- W1970826261 cites W2024592727 @default.
- W1970826261 cites W2026607364 @default.
- W1970826261 cites W2028070445 @default.
- W1970826261 cites W2028085984 @default.
- W1970826261 cites W2028140379 @default.
- W1970826261 cites W2028483223 @default.
- W1970826261 cites W2029276500 @default.
- W1970826261 cites W2029317616 @default.
- W1970826261 cites W2030398428 @default.
- W1970826261 cites W2030616951 @default.
- W1970826261 cites W2030966943 @default.
- W1970826261 cites W2031663826 @default.
- W1970826261 cites W2032459218 @default.
- W1970826261 cites W2032645602 @default.