Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970830015> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W1970830015 abstract "Background: Approximately 80% of human breast carcinomas present as estrogen receptor α-positive (ER+ve) disease and ER status is a critical factor in treatment decision-making. However, ER+ve tumors are heterogeneous in both their molecular profiles and response to therapy. Up to 50% of patients derive little or no clinical benefit from treatment and many exhibit de novo or intrinsic resistance to hormonal therapy. Aim: To investigate factors associated with the level of expression of the ER gene that may be potential determinants of the biology of ER+ve tumors. Methods: Pre- and 2wk post-anastrozole tumor biopsies were obtained from 104 postmenopausal women with stage I to IIIB ER+ early breast cancer. RNA extracted from biopsies was analyzed on Illumina 48K microarrays and quantitative trait analysis by Spearman correlation was used to identify genes whose expression in tumors correlated significantly with ESR1. Results: Expression of three previously uncharacterized open reading frames (ORFs) located immediately upstream of ESR1 on chromosome 6q21, RMND1, C6ORF97 and C6ORF211, were highly correlated with ESR1 (Rs=0.672, 0.637 and 0.546 respectively, p Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2916." @default.
- W1970830015 created "2016-06-24" @default.
- W1970830015 creator A5046016658 @default.
- W1970830015 creator A5048117340 @default.
- W1970830015 creator A5055394073 @default.
- W1970830015 creator A5057002841 @default.
- W1970830015 creator A5057689412 @default.
- W1970830015 creator A5059731799 @default.
- W1970830015 creator A5060583508 @default.
- W1970830015 creator A5079758317 @default.
- W1970830015 date "2010-04-15" @default.
- W1970830015 modified "2023-09-27" @default.
- W1970830015 title "Abstract 2916: Novel genes closely adjacent to and coexpressed with ESR1 affect proliferation in ER+ve breast tumors" @default.
- W1970830015 doi "https://doi.org/10.1158/1538-7445.am10-2916" @default.
- W1970830015 hasPublicationYear "2010" @default.
- W1970830015 type Work @default.
- W1970830015 sameAs 1970830015 @default.
- W1970830015 citedByCount "0" @default.
- W1970830015 crossrefType "proceedings-article" @default.
- W1970830015 hasAuthorship W1970830015A5046016658 @default.
- W1970830015 hasAuthorship W1970830015A5048117340 @default.
- W1970830015 hasAuthorship W1970830015A5055394073 @default.
- W1970830015 hasAuthorship W1970830015A5057002841 @default.
- W1970830015 hasAuthorship W1970830015A5057689412 @default.
- W1970830015 hasAuthorship W1970830015A5059731799 @default.
- W1970830015 hasAuthorship W1970830015A5060583508 @default.
- W1970830015 hasAuthorship W1970830015A5079758317 @default.
- W1970830015 hasConcept C121608353 @default.
- W1970830015 hasConcept C126322002 @default.
- W1970830015 hasConcept C143998085 @default.
- W1970830015 hasConcept C172313692 @default.
- W1970830015 hasConcept C502942594 @default.
- W1970830015 hasConcept C530470458 @default.
- W1970830015 hasConcept C71924100 @default.
- W1970830015 hasConcept C84606932 @default.
- W1970830015 hasConcept C86803240 @default.
- W1970830015 hasConceptScore W1970830015C121608353 @default.
- W1970830015 hasConceptScore W1970830015C126322002 @default.
- W1970830015 hasConceptScore W1970830015C143998085 @default.
- W1970830015 hasConceptScore W1970830015C172313692 @default.
- W1970830015 hasConceptScore W1970830015C502942594 @default.
- W1970830015 hasConceptScore W1970830015C530470458 @default.
- W1970830015 hasConceptScore W1970830015C71924100 @default.
- W1970830015 hasConceptScore W1970830015C84606932 @default.
- W1970830015 hasConceptScore W1970830015C86803240 @default.
- W1970830015 hasLocation W19708300151 @default.
- W1970830015 hasOpenAccess W1970830015 @default.
- W1970830015 hasPrimaryLocation W19708300151 @default.
- W1970830015 hasRelatedWork W1513714274 @default.
- W1970830015 hasRelatedWork W1553287783 @default.
- W1970830015 hasRelatedWork W1557810484 @default.
- W1970830015 hasRelatedWork W2024543108 @default.
- W1970830015 hasRelatedWork W2077545901 @default.
- W1970830015 hasRelatedWork W2095659848 @default.
- W1970830015 hasRelatedWork W2169015185 @default.
- W1970830015 hasRelatedWork W2314918700 @default.
- W1970830015 hasRelatedWork W2318886480 @default.
- W1970830015 hasRelatedWork W2324102602 @default.
- W1970830015 hasRelatedWork W2395496866 @default.
- W1970830015 hasRelatedWork W2527091694 @default.
- W1970830015 hasRelatedWork W2592453975 @default.
- W1970830015 hasRelatedWork W2623010342 @default.
- W1970830015 hasRelatedWork W2898273260 @default.
- W1970830015 hasRelatedWork W2944363718 @default.
- W1970830015 hasRelatedWork W2944525796 @default.
- W1970830015 hasRelatedWork W2975561619 @default.
- W1970830015 hasRelatedWork W2998770009 @default.
- W1970830015 hasRelatedWork W3096093869 @default.
- W1970830015 isParatext "false" @default.
- W1970830015 isRetracted "false" @default.
- W1970830015 magId "1970830015" @default.
- W1970830015 workType "article" @default.