Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970862646> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1970862646 endingPage "175" @default.
- W1970862646 startingPage "171" @default.
- W1970862646 abstract "This study was carried out to determine the effect of metoclopramide on the absorption of lamotrigine when the two drugs were given concurrently by the oral route in rabbits. The first group of animals was given lamotrigine (20 mg/kg, p.o.) alone and the second group was given the same dose of lamotrigine together with metoclopramide (3 mg/kg, p.o.) and plasma samples were collected at different time intervals following drug administration. The concentrations of lamotrigine in plasma were determined by using a high-performance liquid chromatographic (HPLC) method. Co-administration of lamotrigine with metoclopramide resulted in a significant increase (P < 0.05) in the mean maximum plasma concentration (Cmax), mean area under the plasma concentration-time curve (AUC) and a significant decrease (P < 0.05) in the mean time to reach maximum concentration (Tmax) as compared to those obtained for lamotrigine alone. No significant changes were observed in the elimination half-life (t12) of lamotrigine when it was administered together with metoclopramide. These results suggest an increase in the total absorption of lamotrigine when it is administered concurrently with metoclopramide." @default.
- W1970862646 created "2016-06-24" @default.
- W1970862646 creator A5035868919 @default.
- W1970862646 date "1996-11-01" @default.
- W1970862646 modified "2023-10-16" @default.
- W1970862646 title "Effect of metoclopramide on lamotrigine absorption in rabbits" @default.
- W1970862646 cites W1969055818 @default.
- W1970862646 cites W1973714575 @default.
- W1970862646 cites W2001449668 @default.
- W1970862646 cites W2007711114 @default.
- W1970862646 cites W2022293150 @default.
- W1970862646 cites W2023281672 @default.
- W1970862646 cites W2025392650 @default.
- W1970862646 cites W2043818223 @default.
- W1970862646 cites W2060035719 @default.
- W1970862646 cites W2070435801 @default.
- W1970862646 cites W2072294299 @default.
- W1970862646 cites W2079931304 @default.
- W1970862646 cites W2119093004 @default.
- W1970862646 cites W2472611300 @default.
- W1970862646 cites W4244479235 @default.
- W1970862646 cites W4323253271 @default.
- W1970862646 doi "https://doi.org/10.1016/s0378-5173(96)04744-8" @default.
- W1970862646 hasPublicationYear "1996" @default.
- W1970862646 type Work @default.
- W1970862646 sameAs 1970862646 @default.
- W1970862646 citedByCount "3" @default.
- W1970862646 countsByYear W19708626462012 @default.
- W1970862646 countsByYear W19708626462013 @default.
- W1970862646 crossrefType "journal-article" @default.
- W1970862646 hasAuthorship W1970862646A5035868919 @default.
- W1970862646 hasConcept C112705442 @default.
- W1970862646 hasConcept C118552586 @default.
- W1970862646 hasConcept C121332964 @default.
- W1970862646 hasConcept C125287762 @default.
- W1970862646 hasConcept C185592680 @default.
- W1970862646 hasConcept C22979827 @default.
- W1970862646 hasConcept C24890656 @default.
- W1970862646 hasConcept C2777056448 @default.
- W1970862646 hasConcept C2778186239 @default.
- W1970862646 hasConcept C2778479196 @default.
- W1970862646 hasConcept C2778802184 @default.
- W1970862646 hasConcept C2780852908 @default.
- W1970862646 hasConcept C3020079912 @default.
- W1970862646 hasConcept C42219234 @default.
- W1970862646 hasConcept C71924100 @default.
- W1970862646 hasConcept C76318530 @default.
- W1970862646 hasConcept C98274493 @default.
- W1970862646 hasConceptScore W1970862646C112705442 @default.
- W1970862646 hasConceptScore W1970862646C118552586 @default.
- W1970862646 hasConceptScore W1970862646C121332964 @default.
- W1970862646 hasConceptScore W1970862646C125287762 @default.
- W1970862646 hasConceptScore W1970862646C185592680 @default.
- W1970862646 hasConceptScore W1970862646C22979827 @default.
- W1970862646 hasConceptScore W1970862646C24890656 @default.
- W1970862646 hasConceptScore W1970862646C2777056448 @default.
- W1970862646 hasConceptScore W1970862646C2778186239 @default.
- W1970862646 hasConceptScore W1970862646C2778479196 @default.
- W1970862646 hasConceptScore W1970862646C2778802184 @default.
- W1970862646 hasConceptScore W1970862646C2780852908 @default.
- W1970862646 hasConceptScore W1970862646C3020079912 @default.
- W1970862646 hasConceptScore W1970862646C42219234 @default.
- W1970862646 hasConceptScore W1970862646C71924100 @default.
- W1970862646 hasConceptScore W1970862646C76318530 @default.
- W1970862646 hasConceptScore W1970862646C98274493 @default.
- W1970862646 hasIssue "2" @default.
- W1970862646 hasLocation W19708626461 @default.
- W1970862646 hasOpenAccess W1970862646 @default.
- W1970862646 hasPrimaryLocation W19708626461 @default.
- W1970862646 hasRelatedWork W1982777678 @default.
- W1970862646 hasRelatedWork W2011607394 @default.
- W1970862646 hasRelatedWork W2051808886 @default.
- W1970862646 hasRelatedWork W2053092589 @default.
- W1970862646 hasRelatedWork W2056938528 @default.
- W1970862646 hasRelatedWork W2057097799 @default.
- W1970862646 hasRelatedWork W2331297863 @default.
- W1970862646 hasRelatedWork W2415617594 @default.
- W1970862646 hasRelatedWork W2766550598 @default.
- W1970862646 hasRelatedWork W4224326956 @default.
- W1970862646 hasVolume "144" @default.
- W1970862646 isParatext "false" @default.
- W1970862646 isRetracted "false" @default.
- W1970862646 magId "1970862646" @default.
- W1970862646 workType "article" @default.