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- W1970874887 abstract "Summary Apoptosis of macrophages infected with pathogenic mycobacteria is an alternative host defence capable of removing the environment supporting bacterial growth. In this work the influence of virulence and bacterial load on apoptosis of alveolar macrophages during the initial phase of infection by Mycobacterium bovis was investigated. BALB/c mice were infected intratracheally with high or low doses of the virulent (ATCC19274) or attenuated (bacillus Calmette–Guérin Moreau) strains of M. bovis . The frequency of macrophage apoptosis, the growth of mycobacteria in macrophages, and the in situ levels of the cytokines tumour necrosis factor‐α (TNF‐α), interleukin‐10 (IL‐10) and IL‐12 and of the anti‐apoptotic protein Bcl‐2 were measured at day 3 and day 7 post‐infection. An increase of macrophage apoptosis was observed after infection with both strains but the virulent strain induced less apoptosis than the attenuated strain. On the 3rd day after infection with the virulent strain macrophage apoptosis was reduced in the high‐dose group, while on the 7th day post‐infection macrophage apoptosis was reduced in the low‐dose group. Inhibition of apoptosis was correlated with increased production of IL‐10, reduced production of TNF‐α and increased production of Bcl‐2. In addition, the production of IL‐12 was reduced at points where the lowest levels of macrophage apoptosis were observed. Our results indicate that virulent mycobacteria are able to modulate macrophage apoptosis to an extent dependent on the intracellular bacterial burden, which benefits its intracellular growth and dissemination to adjacent cells." @default.
- W1970874887 created "2016-06-24" @default.
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- W1970874887 date "2009-08-04" @default.
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- W1970874887 title "Apoptosis of macrophages during pulmonary<i>Mycobacterium bovis</i>infection: correlation with intracellular bacillary load and cytokine levels" @default.
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- W1970874887 doi "https://doi.org/10.1111/j.1365-2567.2009.03062.x" @default.
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