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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970881569> ?p ?o ?g. }

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• W1970881569 abstract "Hypoxia-ischaemia produces permanent brain damage by processes that continue for many hours after reoxygenation/reperfusion. This provides a window of opportunity for therapy aimed at preventing further loss of brain cells. Reducing brain temperature by 2–6°C for 3–72 h after reoxygenation/reperfusion has been shown to reduce brain damage by 25–80% in controlled trials with six different neonatal animal models of hypoxia-ischaemia. No adverse effects from mild hypothermia have been documented. The mechanisms of protection are unknown but may include a reduction in extracellular excitotoxic amino acids, reduced nitric oxide synthesis and inhibition of apoptosis. Mild hypothermia is currently the most promising clinically feasible neural rescue therapy for full-term infants at risk of developing hypoxic-ischaemic encephalopathy, but clinical use must be restricted to approved trial protocols." @default.
• W1970881569 created "2016-06-24" @default.
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• W1970881569 date "1997-10-01" @default.
• W1970881569 modified "2023-09-27" @default.
• W1970881569 title "Keeping a cool head, post-hypoxic hypothermia–an old idea revisited" @default.
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• W1970881569 doi "https://doi.org/10.1111/j.1651-2227.1997.tb14799.x" @default.
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