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- W1970888906 abstract "An association between some inflammatory diseases and the metabolic syndrome has been reported. Chronic urticaria (CU) is a chronic inflammatory skin disease characterized by infiltrating T cells, eosinophils and neutrophils. This study was aimed to investigate the prevalence and clinical characteristics of metabolic syndrome in patients with CU. A hospital-based cross-sectional study on 131 CU patients (49 males and 82 females, mean age 40.5 years) was performed. Metabolic syndrome was diagnosed in the presence of three or more criteria of the NCEP ATP III (2001). The disease activity of CU was assessed by the UAS, a total score of 0-15. Serum CRP and TNF-α concentrations were measured by ELISA assay using commercially available reagents. Thirty-two (27.1%) patients had a metabolic syndrome. CU patients with metabolic syndrome were older and had higher levels of complement 3 and 4 and serum ECP and TNF-α and showed higher mean UAS compared with CU patients without metabolic syndrome. No significant correlations were found between the metabolic syndrome, and presence of auto-antibodies, disease duration, serum total IgE levels in CU patients. The proportion of patients in uncontrolled status for 3 months of treatment was significantly higher in those with metabolic syndrome. CU patients have a higher prevalence of metabolic syndrome. TNF-α-associated systemic inflammation could be a common pathogenic mechanism of CU and metabolic syndrome. We suggest patients with severe and uncontrolled CU should be evaluated for metabolic syndrome to correct cardiovascular risk factors as well as to improve CU outcomes." @default.
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- W1970888906 date "2012-02-01" @default.
- W1970888906 modified "2023-09-27" @default.
- W1970888906 title "Metabolic Syndrome In Patients With Chronic Urticaria" @default.
- W1970888906 doi "https://doi.org/10.1016/j.jaci.2011.12.123" @default.
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