Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970888935> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W1970888935 endingPage "1104" @default.
- W1970888935 startingPage "1101" @default.
- W1970888935 abstract "Atherosclerotic peripheral vascular disease is symptomatic as intermittent claudication in 2-3% of men and 1-2 % of women aged over 60 years. However, the prevalence of asymptomatic peripheral vascular disease, generally shown by a reduced ankle to brachial systolic pressure index, is three to four times greater. Peripheral vascular disease is also a significant cause of hospital admission, and is an important predicator of cardiovascular mortality. Pain at rest and critical ischaemia are usually the result of progression of atherosclerotic disease, leading to multilevel arterial occlusion. Other causes of arterial insufficiency—including fibromuscular dysplasia, inflammatory conditions, and congenital malformations—are much rarer.Therapeutic objectives in peripheral vascular disease include relieving symptoms and preventing the disease, and any associated events, progressing.View this table:Antithrombotic therapy in peripheral vascular diseaseThe symptoms of peripheral vascular disease are progressive. A claudicating patient encouraged to exercise tends to report a symptomatic improvement. This effect is generally not accepted to be an improvement in the diseased segment of blood vessel, but the formation of collateral vessels perfusing the ischaemic tissue.Vasodilating agents, such as naftidrofuryl, have little value in managing claudication and peripheral vascular disease as their effect is small and does not stop progression of the disease. Cilostazol has been shown to increase absolute walking distance in some patients by up to 47%. However, it has no clear antithrombotic effect and has not been shown to stop disease progression.Unfortunately, not all progression is amenable to improvement and, without the appropriate risk factor management, progression to rest pain and necrosis can be rapid.The role of aspirin as an antiplatelet agent has been shown to be beneficial beyond doubt. In peripheral vascular disease it reduces the frequency of thrombotic events in the peripheral arteries and reduces overall cardiovascular mortality in claudicating patients. The dose …" @default.
- W1970888935 created "2016-06-24" @default.
- W1970888935 creator A5031810695 @default.
- W1970888935 creator A5053449030 @default.
- W1970888935 creator A5088579117 @default.
- W1970888935 date "2002-11-09" @default.
- W1970888935 modified "2023-09-25" @default.
- W1970888935 title "ABC of antithrombotic therapy: Antithrombotic therapy in peripheral vascular disease" @default.
- W1970888935 doi "https://doi.org/10.1136/bmj.325.7372.1101" @default.
- W1970888935 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1124585" @default.
- W1970888935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12424175" @default.
- W1970888935 hasPublicationYear "2002" @default.
- W1970888935 type Work @default.
- W1970888935 sameAs 1970888935 @default.
- W1970888935 citedByCount "3" @default.
- W1970888935 crossrefType "journal-article" @default.
- W1970888935 hasAuthorship W1970888935A5031810695 @default.
- W1970888935 hasAuthorship W1970888935A5053449030 @default.
- W1970888935 hasAuthorship W1970888935A5088579117 @default.
- W1970888935 hasBestOaLocation W19708889352 @default.
- W1970888935 hasConcept C126322002 @default.
- W1970888935 hasConcept C141071460 @default.
- W1970888935 hasConcept C177713679 @default.
- W1970888935 hasConcept C2777015399 @default.
- W1970888935 hasConcept C2777466421 @default.
- W1970888935 hasConcept C2779134260 @default.
- W1970888935 hasConcept C2909817843 @default.
- W1970888935 hasConcept C3018348675 @default.
- W1970888935 hasConcept C46762472 @default.
- W1970888935 hasConcept C60644358 @default.
- W1970888935 hasConcept C71924100 @default.
- W1970888935 hasConcept C86803240 @default.
- W1970888935 hasConceptScore W1970888935C126322002 @default.
- W1970888935 hasConceptScore W1970888935C141071460 @default.
- W1970888935 hasConceptScore W1970888935C177713679 @default.
- W1970888935 hasConceptScore W1970888935C2777015399 @default.
- W1970888935 hasConceptScore W1970888935C2777466421 @default.
- W1970888935 hasConceptScore W1970888935C2779134260 @default.
- W1970888935 hasConceptScore W1970888935C2909817843 @default.
- W1970888935 hasConceptScore W1970888935C3018348675 @default.
- W1970888935 hasConceptScore W1970888935C46762472 @default.
- W1970888935 hasConceptScore W1970888935C60644358 @default.
- W1970888935 hasConceptScore W1970888935C71924100 @default.
- W1970888935 hasConceptScore W1970888935C86803240 @default.
- W1970888935 hasIssue "7372" @default.
- W1970888935 hasLocation W19708889351 @default.
- W1970888935 hasLocation W19708889352 @default.
- W1970888935 hasLocation W19708889353 @default.
- W1970888935 hasOpenAccess W1970888935 @default.
- W1970888935 hasPrimaryLocation W19708889351 @default.
- W1970888935 hasRelatedWork W1781122166 @default.
- W1970888935 hasRelatedWork W2134921421 @default.
- W1970888935 hasRelatedWork W2143483143 @default.
- W1970888935 hasRelatedWork W2158117084 @default.
- W1970888935 hasRelatedWork W2312357239 @default.
- W1970888935 hasRelatedWork W2406760059 @default.
- W1970888935 hasRelatedWork W4280575732 @default.
- W1970888935 hasRelatedWork W4367175234 @default.
- W1970888935 hasRelatedWork W2073113019 @default.
- W1970888935 hasRelatedWork W2521952050 @default.
- W1970888935 hasVolume "325" @default.
- W1970888935 isParatext "false" @default.
- W1970888935 isRetracted "false" @default.
- W1970888935 magId "1970888935" @default.
- W1970888935 workType "article" @default.