FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970895936> ?p ?o ?g. }

• W1970895936 endingPage "471" @default.
• W1970895936 startingPage "463" @default.
• W1970895936 abstract "Organochlorine pesticides are used worldwide. To our knowledge there have been no studies dealing with the effects of these agents under in vitro conditions on human natural killer (NK) cell cytotoxic function. NK cells play a central role in immune defense against tumor development and viral infections. Thus, any agent that interferes with the ability of NK cells to lyse their targets could increase the risk of tumor incidence and/or viral infections. In this study, we examined the effects of organochlorine pesticides and some of their breakdown products on the ability of human NK cells to lyse tumor cells. A total of 11 compounds were tested. The compounds were tested in both purified NK cells as well as a cell preparation that contained other mononuclear cells (predominantly T cells) and NK lymphocytes (referred to as T/NK cells). Lymphocytes were exposed to the compounds for periods of time ranging from 1 hour to 6 days. Exposure of highly purified NK cells to 5 μ M α-chlordane, γ-chlordane, 4,4'-DDT, heptachlor, oxychlordane, or pentachlorophenol (PCP) inhibited their ability to destroy K562 tumor-cells by 88±5, 92±8, 61±13%, 64±10%, 69±11%, 76±12%, respectively, after a 24h exposure. The loss of cytotoxic function seen with α-and γ-chlordane remained essentially constant out to 6 days, while that seen with 4,4'-DDT, oxychordane and PCP increased with longer exposures (6 d). PCP was the most effective of the compounds tested at decreasing NK function. Of the compounds that caused decreased lytic function when tested in purified NK cells, only PCP and oxychordane decreased the lytic function of the T/NK cell preparation after any exposure. The results provide evidence of relative toxic potential for the 11 compounds and their immunomodulatory effects on other mononuclear cells (such as T-cells, B-cells, and monocytes) as well as NK lymphocyte function." @default.
• W1970895936 created "2016-06-24" @default.
• W1970895936 creator A5036893787 @default.
• W1970895936 creator A5055395674 @default.
• W1970895936 creator A5083249852 @default.
• W1970895936 creator A5090757520 @default.
• W1970895936 date "2004-10-01" @default.
• W1970895936 modified "2023-10-16" @default.
• W1970895936 title "Immunomodulation of human natural killer cell cytotoxic function by organochlorine pesticides" @default.
• W1970895936 cites W1556867369 @default.
• W1970895936 cites W1965355819 @default.
• W1970895936 cites W1970752831 @default.
• W1970895936 cites W1972932873 @default.
• W1970895936 cites W1985958471 @default.
• W1970895936 cites W1988579977 @default.
• W1970895936 cites W2005792381 @default.
• W1970895936 cites W2008221423 @default.
• W1970895936 cites W2013014801 @default.
• W1970895936 cites W2013087447 @default.
• W1970895936 cites W2023828666 @default.
• W1970895936 cites W2025885984 @default.
• W1970895936 cites W2028045492 @default.
• W1970895936 cites W2028411717 @default.
• W1970895936 cites W2040682268 @default.
• W1970895936 cites W2057687626 @default.
• W1970895936 cites W2063709533 @default.
• W1970895936 cites W2064618512 @default.
• W1970895936 cites W2075660527 @default.
• W1970895936 cites W2108704542 @default.
• W1970895936 cites W2114948126 @default.
• W1970895936 cites W2123159968 @default.
• W1970895936 cites W2139250003 @default.
• W1970895936 cites W2151723746 @default.
• W1970895936 cites W4245943750 @default.
• W1970895936 cites W51471118 @default.
• W1970895936 doi "https://doi.org/10.1191/0960327104ht477oa" @default.
• W1970895936 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15553171" @default.
• W1970895936 hasPublicationYear "2004" @default.
• W1970895936 type Work @default.
• W1970895936 sameAs 1970895936 @default.
• W1970895936 citedByCount "38" @default.
• W1970895936 countsByYear W19708959362012 @default.
• W1970895936 countsByYear W19708959362013 @default.
• W1970895936 countsByYear W19708959362014 @default.
• W1970895936 countsByYear W19708959362015 @default.
• W1970895936 countsByYear W19708959362016 @default.
• W1970895936 countsByYear W19708959362017 @default.
• W1970895936 countsByYear W19708959362018 @default.
• W1970895936 countsByYear W19708959362019 @default.
• W1970895936 countsByYear W19708959362020 @default.
• W1970895936 countsByYear W19708959362021 @default.
• W1970895936 crossrefType "journal-article" @default.
• W1970895936 hasAuthorship W1970895936A5036893787 @default.
• W1970895936 hasAuthorship W1970895936A5055395674 @default.
• W1970895936 hasAuthorship W1970895936A5083249852 @default.
• W1970895936 hasAuthorship W1970895936A5090757520 @default.
• W1970895936 hasConcept C109316439 @default.
• W1970895936 hasConcept C1491633281 @default.
• W1970895936 hasConcept C154317977 @default.
• W1970895936 hasConcept C161176658 @default.
• W1970895936 hasConcept C171122931 @default.
• W1970895936 hasConcept C185592680 @default.
• W1970895936 hasConcept C202751555 @default.
• W1970895936 hasConcept C203014093 @default.
• W1970895936 hasConcept C2778102761 @default.
• W1970895936 hasConcept C2780799252 @default.
• W1970895936 hasConcept C55493867 @default.
• W1970895936 hasConcept C6557445 @default.
• W1970895936 hasConcept C86803240 @default.
• W1970895936 hasConcept C8891405 @default.
• W1970895936 hasConcept C98274493 @default.
• W1970895936 hasConceptScore W1970895936C109316439 @default.
• W1970895936 hasConceptScore W1970895936C1491633281 @default.
• W1970895936 hasConceptScore W1970895936C154317977 @default.
• W1970895936 hasConceptScore W1970895936C161176658 @default.
• W1970895936 hasConceptScore W1970895936C171122931 @default.
• W1970895936 hasConceptScore W1970895936C185592680 @default.
• W1970895936 hasConceptScore W1970895936C202751555 @default.
• W1970895936 hasConceptScore W1970895936C203014093 @default.
• W1970895936 hasConceptScore W1970895936C2778102761 @default.
• W1970895936 hasConceptScore W1970895936C2780799252 @default.
• W1970895936 hasConceptScore W1970895936C55493867 @default.
• W1970895936 hasConceptScore W1970895936C6557445 @default.
• W1970895936 hasConceptScore W1970895936C86803240 @default.
• W1970895936 hasConceptScore W1970895936C8891405 @default.
• W1970895936 hasConceptScore W1970895936C98274493 @default.
• W1970895936 hasIssue "10" @default.
• W1970895936 hasLocation W19708959361 @default.
• W1970895936 hasLocation W19708959362 @default.
• W1970895936 hasOpenAccess W1970895936 @default.
• W1970895936 hasPrimaryLocation W19708959361 @default.
• W1970895936 hasRelatedWork W1970895936 @default.
• W1970895936 hasRelatedWork W1990434843 @default.
• W1970895936 hasRelatedWork W1996619799 @default.
• W1970895936 hasRelatedWork W2016296153 @default.
• W1970895936 hasRelatedWork W2045629642 @default.
• W1970895936 hasRelatedWork W2048686206 @default.
• W1970895936 hasRelatedWork W2054367862 @default.

• next