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- W1970898981 abstract "Novel to our laboratory, we have demonstrated that inflammation-induced preterm birth (II-PTB) results in perturbations in neuronal morphology and function. The objective of our study was to elucidate the mechanisms of this neuronal injury and to investigate whether the neurological damage could be reversed by mediators produced by the normal glial or neuronal milieu. A mouse model of intrauterine inflammation was utilized for these studies. At E15, LPS was injected in to uterine horn; controls received no intervention. From each treatment group, fetal brains (fb) were harvested and either cortical cultures (neurons) or co-culture (glial +neurons) were created: 1) control cortical culture (CN) (n=12fb); 2) LPS-treated cortical culture (LN) (n=12); 3) control co-culture (CCC) (n=12); 4) LPS-treated co-culture (LCC) (n=12). Co-cultures were characterized. At 24 hours, CN and LN were treated with media from LCC, LN, CCC and CN. Confocal microscopy (NF200, MAP, GFAP, NeuN, A4B5) was performed. Morphology and number of dendritic processes recorded at division day 3 (DD3) for different treatment groups. At 48 hours after treatment (DD3), media from LN and LCC induced morphological changes in CN comparable to LN .The neurological damage caused by in vivo exposure to inflammation could not be reversed by media from CN or CCC. Culture characterization at DD7, showed no significant changes between controls and LPS treated co-cultures (74% astrocytes, 23% neurons and 2% microglia); however, LCC showed neuronal morphological changes comparable to that of LN, including decreased aggregation and abnormal growth of processes. II-PTB may be responsible for irreversible neuronal damage which may lead to a long term adverse neurodevelopment in ex-preterm infants including motor, cognitive and behavioral abnormalities. This work suggests that traditional lesions such as PVL or WMD may not be required for adverse long-term outcome and strategies to prevent specific neuronal injury are now warranted." @default.
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- W1970898981 date "2008-12-01" @default.
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- W1970898981 title "21: Beyond white matter damage: Neuronal injury in preterm birth" @default.
- W1970898981 doi "https://doi.org/10.1016/j.ajog.2008.09.049" @default.
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