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• W1970902020 abstract "Systemic administration of the amphetamine analogue, 3,4-methylenedioxymethamphetamine (MDMA) produced a dose-dependent increase in the extracellular concentration of dopamine (DA) in the striatum as measured by in vivo microdialysis in awake, freely-moving rats. The extracellular concentration of the DA metabolite, 3,4-dihydroxyphenylacetic acid (DOPAC), was significantly decreased in dialysate samples following the administration of MDMA (10 and 20 mg/kg, i.p.). The serotonin-2 (5-HT2) antagonist ketanserin (3 mg/kg, i.p.) had no effect on the extracellular concentration of DA or DOPAC in the striatum of vehicle- treated rats. The administration of ketanserin (3 mg/kg) 1 hr prior to MDMA (20 mg/kg) significantly attenuated the MDMA- induced increase in the extracellular concentration of DA without affecting the decrease in DOPAC concentrations. These data are suggestive that MDMA administration increases DA release in the striatum of awake, freely-moving rats. In addition, MDMA-induced increase in the extracellular concentration of DA in the striatum is mediated, in part, via 5-HT2 receptor mechanisms." @default.
• W1970902020 created "2016-06-24" @default.
• W1970902020 creator A5048838123 @default.
• W1970902020 date "1990-01-01" @default.
• W1970902020 modified "2023-10-18" @default.
• W1970902020 title "Ketanserin pretreatment attenuates MDMA-induced dopamine release in the striatum as measured by microdialysis" @default.
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• W1970902020 doi "https://doi.org/10.1016/0024-3205(90)90484-9" @default.
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