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• W1970902749 abstract "Uniform 8-methoxypsoralen (8-MOP) absorption from the gastrointestinal tract is necessary to avoid day-to-day variations in 8-MOP plasma levels when treating patients with psoriasis by photochemotherapy. Because of its low water solubility, particle size and crystal form of the 8-MOP can significantly influence its bioavailability. The presentation form is also important, as is shown by the present study in which 8-MOP plasma levels were compared in thirty patients after oral administration in three different forms: formulation A consisted of gelatin capsules containing 8-MOP with a mean particle size of 200 μ; formulation B consisted of gelatin capsules containing 8-MOP in microcrystalline form with particle size between 20 μ. and 30 μ; formulation C contained the same microcrystalline 8-MOP but in an emulsion base. Significantly higher plasma levels were found with formulations B and C than with formulation A. Furthermore, the individual differences in plasma profiles were markedly less with the emulsion base than with the capsule forms. Therefore, the clinical use of 8-MOP in emulsion form would constitute a major step in 8-MOP dose standardization and could lead to better control of subjective side effects and better therapeutic results." @default.
• W1970902749 created "2016-06-24" @default.
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• W1970902749 date "1985-05-01" @default.
• W1970902749 modified "2023-09-25" @default.
• W1970902749 title "Standardizing 8-methoxypsoralen plasma profiles by using an emulsion form" @default.
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• W1970902749 doi "https://doi.org/10.1016/s0190-9622(85)70102-8" @default.
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