Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970904498> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1970904498 endingPage "663" @default.
- W1970904498 startingPage "660" @default.
- W1970904498 abstract "Both thyrotropin-releasing hormone (TRH) and RO 15-4513 antagonize ethanol-induced depression, but this common property does not infer that both compounds share similar mechanisms of action. In the present studies, both TRH (30 mg/kg, i.p.) and RO 15-4513 (10 mg/kg, i.p.) reversed ethanol-induced depression of locomotor activity, in accord with previous reports. However, the benzodiazepine antagonist, RO 15-1788, blocked this action of RO 15-4513, while exerting no effect on the analeptic action of TRH. Using a model of seizure activity electrically elicited from the inferior colliculus, ethanol exerted a dose-related attenuation of seizure activity. This anticonvulsant action of ethanol was not altered by TRH (30 mg/kg, i.p.), but RO 15-4513 (3 mg/kg) reversed the effect of the 0.5, but not the 1.0 g/kg, dose of ethanol. In addition, pretreatment with RO 15-4513 (1 or 3 mg/kg, i.p.), but not TRH (30 mg/kg, i.p.), caused seizure generalization into the forebrain following inferior collicular stimulation, further verifying the proconvulsant properties of RO 15-4513. In conclusion, the analeptic action of TRH appears independent of benzodiazepine activity, and in contrast to RO 15-4513, TRH does not exhibit proconvulsant properties. Furthermore, because TRH did not antagonize both depressant actions of ethanol studied, it appears unlikely that TRH directly interacts with the molecular basis of ethanol action." @default.
- W1970904498 created "2016-06-24" @default.
- W1970904498 creator A5012544252 @default.
- W1970904498 creator A5026416051 @default.
- W1970904498 date "1989-10-01" @default.
- W1970904498 modified "2023-09-27" @default.
- W1970904498 title "Mechanistic and Functional Divergence Between Thyrotropin-releasing Hormone and RO 15-4513 Interactions with Ethanol" @default.
- W1970904498 cites W1876211719 @default.
- W1970904498 cites W1900549838 @default.
- W1970904498 cites W1908844461 @default.
- W1970904498 cites W1976130361 @default.
- W1970904498 cites W1990744785 @default.
- W1970904498 cites W2015571647 @default.
- W1970904498 cites W2023935196 @default.
- W1970904498 cites W2028650350 @default.
- W1970904498 cites W2030813631 @default.
- W1970904498 cites W2039328344 @default.
- W1970904498 cites W2045355411 @default.
- W1970904498 cites W2059962646 @default.
- W1970904498 cites W2061341649 @default.
- W1970904498 cites W2080707458 @default.
- W1970904498 cites W2081635166 @default.
- W1970904498 cites W2129035678 @default.
- W1970904498 cites W2331748882 @default.
- W1970904498 doi "https://doi.org/10.1111/j.1530-0277.1989.tb00400.x" @default.
- W1970904498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2885909" @default.
- W1970904498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2512820" @default.
- W1970904498 hasPublicationYear "1989" @default.
- W1970904498 type Work @default.
- W1970904498 sameAs 1970904498 @default.
- W1970904498 citedByCount "11" @default.
- W1970904498 crossrefType "journal-article" @default.
- W1970904498 hasAuthorship W1970904498A5012544252 @default.
- W1970904498 hasAuthorship W1970904498A5026416051 @default.
- W1970904498 hasBestOaLocation W19709044982 @default.
- W1970904498 hasConcept C118934951 @default.
- W1970904498 hasConcept C126322002 @default.
- W1970904498 hasConcept C134018914 @default.
- W1970904498 hasConcept C15744967 @default.
- W1970904498 hasConcept C169760540 @default.
- W1970904498 hasConcept C170493617 @default.
- W1970904498 hasConcept C185592680 @default.
- W1970904498 hasConcept C24998067 @default.
- W1970904498 hasConcept C2775858608 @default.
- W1970904498 hasConcept C2776216936 @default.
- W1970904498 hasConcept C2776885963 @default.
- W1970904498 hasConcept C2778173252 @default.
- W1970904498 hasConcept C2778186239 @default.
- W1970904498 hasConcept C2780161600 @default.
- W1970904498 hasConcept C55493867 @default.
- W1970904498 hasConcept C71315377 @default.
- W1970904498 hasConcept C71924100 @default.
- W1970904498 hasConcept C98274493 @default.
- W1970904498 hasConceptScore W1970904498C118934951 @default.
- W1970904498 hasConceptScore W1970904498C126322002 @default.
- W1970904498 hasConceptScore W1970904498C134018914 @default.
- W1970904498 hasConceptScore W1970904498C15744967 @default.
- W1970904498 hasConceptScore W1970904498C169760540 @default.
- W1970904498 hasConceptScore W1970904498C170493617 @default.
- W1970904498 hasConceptScore W1970904498C185592680 @default.
- W1970904498 hasConceptScore W1970904498C24998067 @default.
- W1970904498 hasConceptScore W1970904498C2775858608 @default.
- W1970904498 hasConceptScore W1970904498C2776216936 @default.
- W1970904498 hasConceptScore W1970904498C2776885963 @default.
- W1970904498 hasConceptScore W1970904498C2778173252 @default.
- W1970904498 hasConceptScore W1970904498C2778186239 @default.
- W1970904498 hasConceptScore W1970904498C2780161600 @default.
- W1970904498 hasConceptScore W1970904498C55493867 @default.
- W1970904498 hasConceptScore W1970904498C71315377 @default.
- W1970904498 hasConceptScore W1970904498C71924100 @default.
- W1970904498 hasConceptScore W1970904498C98274493 @default.
- W1970904498 hasIssue "5" @default.
- W1970904498 hasLocation W19709044981 @default.
- W1970904498 hasLocation W19709044982 @default.
- W1970904498 hasLocation W19709044983 @default.
- W1970904498 hasLocation W19709044984 @default.
- W1970904498 hasLocation W19709044985 @default.
- W1970904498 hasOpenAccess W1970904498 @default.
- W1970904498 hasPrimaryLocation W19709044981 @default.
- W1970904498 hasRelatedWork W1995816823 @default.
- W1970904498 hasRelatedWork W2017232857 @default.
- W1970904498 hasRelatedWork W2026857001 @default.
- W1970904498 hasRelatedWork W2033894260 @default.
- W1970904498 hasRelatedWork W2106532285 @default.
- W1970904498 hasRelatedWork W2122221387 @default.
- W1970904498 hasRelatedWork W2146333229 @default.
- W1970904498 hasRelatedWork W2325997963 @default.
- W1970904498 hasRelatedWork W4290399282 @default.
- W1970904498 hasRelatedWork W4571987 @default.
- W1970904498 hasVolume "13" @default.
- W1970904498 isParatext "false" @default.
- W1970904498 isRetracted "false" @default.
- W1970904498 magId "1970904498" @default.
- W1970904498 workType "article" @default.