Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970911169> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1970911169 endingPage "1205" @default.
- W1970911169 startingPage "1201" @default.
- W1970911169 abstract "Earlier studies by other investigators have shown that acute exposure of cultured endothelial cells to hypoxic atmospheres inhibits the activity of the angiotensin converting enzyme in situ, resulting in severe but reversible depression of the rate of degradation of bradykinin. We exposed primary cultures of endothelial cells from the pulmonary artery of the pig to a range of hypoxic gas mixtures and measured the activity of the angiotensin converting enzyme in situ using angiotensin I as substrate. Each cell flask was exposed in random sequence to both hypoxic gas mixtures (PO2 29–69 torr) and room air for 40 min in Dulbecco's medium containing angiotensin I at concentrations of 1000 (N = 7), 500 (N = 8) or 100 ng/ml (N = 4). Angiotensin I disappearance rates and angiotensin II generation rates were linear. Recovery of immunoreactive peptide as either angiotensin I or II following 40 min of incubation was 86 ± 17% (S.D.). The rate of increase in angiotensin II concentration in surface medium in room air experiments was 91 ± 51 (S.D.) ng · ml−1 · hr−1. During hypoxia it was 85 ± 42 ng · ml−1 · hr−1. The difference in rates was not significant by paired t analysis. The results of this study are consistent with earlier observations by the authors which suggest that hypoxia-induced depression of angiotensin I conversion in vivo is due to hemodynamic phenomena. Further studies are needed to clarify the role of cellular mechanisms in hypoxia-induced depression of angiotensin metabolism." @default.
- W1970911169 created "2016-06-24" @default.
- W1970911169 creator A5002246155 @default.
- W1970911169 creator A5034742286 @default.
- W1970911169 creator A5056779487 @default.
- W1970911169 creator A5073285551 @default.
- W1970911169 date "1983-04-01" @default.
- W1970911169 modified "2023-09-25" @default.
- W1970911169 title "Effect of hypoxia on the conversion of angiotensin I to II in cultured porcine pulmonary endothelial cells" @default.
- W1970911169 cites W1979470393 @default.
- W1970911169 cites W2021865194 @default.
- W1970911169 cites W2053960683 @default.
- W1970911169 cites W2069064574 @default.
- W1970911169 cites W2088644926 @default.
- W1970911169 cites W2234060871 @default.
- W1970911169 cites W2252744208 @default.
- W1970911169 cites W2294480470 @default.
- W1970911169 cites W2397710792 @default.
- W1970911169 cites W2401029719 @default.
- W1970911169 doi "https://doi.org/10.1016/0006-2952(83)90272-1" @default.
- W1970911169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6303352" @default.
- W1970911169 hasPublicationYear "1983" @default.
- W1970911169 type Work @default.
- W1970911169 sameAs 1970911169 @default.
- W1970911169 citedByCount "6" @default.
- W1970911169 countsByYear W19709111692012 @default.
- W1970911169 countsByYear W19709111692016 @default.
- W1970911169 crossrefType "journal-article" @default.
- W1970911169 hasAuthorship W1970911169A5002246155 @default.
- W1970911169 hasAuthorship W1970911169A5034742286 @default.
- W1970911169 hasAuthorship W1970911169A5056779487 @default.
- W1970911169 hasAuthorship W1970911169A5073285551 @default.
- W1970911169 hasConcept C126322002 @default.
- W1970911169 hasConcept C134018914 @default.
- W1970911169 hasConcept C170493617 @default.
- W1970911169 hasConcept C178790620 @default.
- W1970911169 hasConcept C185592680 @default.
- W1970911169 hasConcept C198710026 @default.
- W1970911169 hasConcept C25642318 @default.
- W1970911169 hasConcept C27016395 @default.
- W1970911169 hasConcept C2779591629 @default.
- W1970911169 hasConcept C2908929049 @default.
- W1970911169 hasConcept C540031477 @default.
- W1970911169 hasConcept C55493867 @default.
- W1970911169 hasConcept C71924100 @default.
- W1970911169 hasConcept C7836513 @default.
- W1970911169 hasConcept C84393581 @default.
- W1970911169 hasConcept C86803240 @default.
- W1970911169 hasConceptScore W1970911169C126322002 @default.
- W1970911169 hasConceptScore W1970911169C134018914 @default.
- W1970911169 hasConceptScore W1970911169C170493617 @default.
- W1970911169 hasConceptScore W1970911169C178790620 @default.
- W1970911169 hasConceptScore W1970911169C185592680 @default.
- W1970911169 hasConceptScore W1970911169C198710026 @default.
- W1970911169 hasConceptScore W1970911169C25642318 @default.
- W1970911169 hasConceptScore W1970911169C27016395 @default.
- W1970911169 hasConceptScore W1970911169C2779591629 @default.
- W1970911169 hasConceptScore W1970911169C2908929049 @default.
- W1970911169 hasConceptScore W1970911169C540031477 @default.
- W1970911169 hasConceptScore W1970911169C55493867 @default.
- W1970911169 hasConceptScore W1970911169C71924100 @default.
- W1970911169 hasConceptScore W1970911169C7836513 @default.
- W1970911169 hasConceptScore W1970911169C84393581 @default.
- W1970911169 hasConceptScore W1970911169C86803240 @default.
- W1970911169 hasIssue "7" @default.
- W1970911169 hasLocation W19709111691 @default.
- W1970911169 hasLocation W19709111692 @default.
- W1970911169 hasOpenAccess W1970911169 @default.
- W1970911169 hasPrimaryLocation W19709111691 @default.
- W1970911169 hasRelatedWork W1992220075 @default.
- W1970911169 hasRelatedWork W2042660006 @default.
- W1970911169 hasRelatedWork W2050645923 @default.
- W1970911169 hasRelatedWork W2077998387 @default.
- W1970911169 hasRelatedWork W2126797993 @default.
- W1970911169 hasRelatedWork W2132612653 @default.
- W1970911169 hasRelatedWork W2149410839 @default.
- W1970911169 hasRelatedWork W2151139437 @default.
- W1970911169 hasRelatedWork W2190649397 @default.
- W1970911169 hasRelatedWork W2744890335 @default.
- W1970911169 hasVolume "32" @default.
- W1970911169 isParatext "false" @default.
- W1970911169 isRetracted "false" @default.
- W1970911169 magId "1970911169" @default.
- W1970911169 workType "article" @default.