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- W1970918705 abstract "Duret and Galtier argue that human-specific sequence divergence and gain of function in the HACNS1 enhancer result from deleterious biased gene conversion (BGC) with no contribution from positive selection. We reinforce our previous conclusion by analyzing hypothesized BGCevents genomewide and assessing the effect of recombination rates on human-accelerated conserved noncoding sequence ascertainment. We also provide evidence that AT → GC substitution bias can coexist with positive selection." @default.
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- W1970918705 date "2009-02-06" @default.
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- W1970918705 title "Response to Comment on Human-Specific Gain of Function in a Developmental Enhancer" @default.
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- W1970918705 doi "https://doi.org/10.1126/science.1166571" @default.
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