Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970919833> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W1970919833 endingPage "293" @default.
- W1970919833 startingPage "290" @default.
- W1970919833 abstract "Background: Gene therapy is expected to play a major role in medical treatment in the future. Several different methods for DNA transfection exist. We evaluated the efficacy and effects of transfection by acoustic energy in a standardized prostate cancer model. Methods: Subcutaneous implantation of Dunning tumors was followed by injection of pEGFP-DNA plasmid. Tumors were treated by acoustic energy with different parameter settings and the transfection rate was assessed by FACScan. Results: Standardized experimental conditions resulted in minor intragroup deviations. Intratumoral injection resulted in a transfection rate of 0.3% (control group). The statistically significant increase of 4.6% in cell transfection rate was gained by applying acoustic energy. Conclusions: DNA transfection of solid tumors can be mediated by the application of acoustic energy. Achieved transfection rates are encouraging and imply therapeutical levels. Prodrug activation or suicide gene therapy are possible fields of investigation in the treatment of prostate cancer." @default.
- W1970919833 created "2016-06-24" @default.
- W1970919833 creator A5037303782 @default.
- W1970919833 creator A5044098380 @default.
- W1970919833 creator A5048419761 @default.
- W1970919833 creator A5065543856 @default.
- W1970919833 creator A5067050215 @default.
- W1970919833 date "2003-12-01" @default.
- W1970919833 modified "2023-10-16" @default.
- W1970919833 title "Prostate cancer transfection by acoustic energy using pEGFP-N1 as reporter gene in the solid Dunning R-3327-MatLu tumor" @default.
- W1970919833 cites W1616824889 @default.
- W1970919833 cites W1844290320 @default.
- W1970919833 cites W1975091878 @default.
- W1970919833 cites W2007972800 @default.
- W1970919833 cites W2012719011 @default.
- W1970919833 cites W2015156947 @default.
- W1970919833 cites W2055979283 @default.
- W1970919833 cites W2058966369 @default.
- W1970919833 cites W2061555550 @default.
- W1970919833 cites W2116060045 @default.
- W1970919833 cites W2138766402 @default.
- W1970919833 doi "https://doi.org/10.1038/sj.pcan.4500667" @default.
- W1970919833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14663469" @default.
- W1970919833 hasPublicationYear "2003" @default.
- W1970919833 type Work @default.
- W1970919833 sameAs 1970919833 @default.
- W1970919833 citedByCount "2" @default.
- W1970919833 countsByYear W19709198332016 @default.
- W1970919833 crossrefType "journal-article" @default.
- W1970919833 hasAuthorship W1970919833A5037303782 @default.
- W1970919833 hasAuthorship W1970919833A5044098380 @default.
- W1970919833 hasAuthorship W1970919833A5048419761 @default.
- W1970919833 hasAuthorship W1970919833A5065543856 @default.
- W1970919833 hasAuthorship W1970919833A5067050215 @default.
- W1970919833 hasBestOaLocation W19709198331 @default.
- W1970919833 hasConcept C104317684 @default.
- W1970919833 hasConcept C111599444 @default.
- W1970919833 hasConcept C121608353 @default.
- W1970919833 hasConcept C126322002 @default.
- W1970919833 hasConcept C153911025 @default.
- W1970919833 hasConcept C2780192828 @default.
- W1970919833 hasConcept C502942594 @default.
- W1970919833 hasConcept C54009773 @default.
- W1970919833 hasConcept C54355233 @default.
- W1970919833 hasConcept C552990157 @default.
- W1970919833 hasConcept C71924100 @default.
- W1970919833 hasConcept C86803240 @default.
- W1970919833 hasConceptScore W1970919833C104317684 @default.
- W1970919833 hasConceptScore W1970919833C111599444 @default.
- W1970919833 hasConceptScore W1970919833C121608353 @default.
- W1970919833 hasConceptScore W1970919833C126322002 @default.
- W1970919833 hasConceptScore W1970919833C153911025 @default.
- W1970919833 hasConceptScore W1970919833C2780192828 @default.
- W1970919833 hasConceptScore W1970919833C502942594 @default.
- W1970919833 hasConceptScore W1970919833C54009773 @default.
- W1970919833 hasConceptScore W1970919833C54355233 @default.
- W1970919833 hasConceptScore W1970919833C552990157 @default.
- W1970919833 hasConceptScore W1970919833C71924100 @default.
- W1970919833 hasConceptScore W1970919833C86803240 @default.
- W1970919833 hasIssue "4" @default.
- W1970919833 hasLocation W19709198331 @default.
- W1970919833 hasLocation W19709198332 @default.
- W1970919833 hasOpenAccess W1970919833 @default.
- W1970919833 hasPrimaryLocation W19709198331 @default.
- W1970919833 hasRelatedWork W1548891476 @default.
- W1970919833 hasRelatedWork W2028721360 @default.
- W1970919833 hasRelatedWork W2290989990 @default.
- W1970919833 hasRelatedWork W2357624417 @default.
- W1970919833 hasRelatedWork W2364737702 @default.
- W1970919833 hasRelatedWork W2371568901 @default.
- W1970919833 hasRelatedWork W2385166666 @default.
- W1970919833 hasRelatedWork W2413079405 @default.
- W1970919833 hasRelatedWork W631446107 @default.
- W1970919833 hasRelatedWork W211985650 @default.
- W1970919833 hasVolume "6" @default.
- W1970919833 isParatext "false" @default.
- W1970919833 isRetracted "false" @default.
- W1970919833 magId "1970919833" @default.
- W1970919833 workType "article" @default.