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- W197096040 abstract "Publisher Summary This chapter discusses the endocrine and metabolic effects of the experimental obesity in humans. All the changes witnessed in spontaneous obesity except for the increase in adipocyte number have been reproduced in experimental obesity. It has been found that endocrine and metabolic changes are associated with gain in weight. Normal subjects fattened by eating a mixed diet require more calories in relation to their body surface area for maintenance of the obese state than they require when at their natural weight and also more than the spontaneously obese generally require. There are marked differences in the ability of normal individuals to gain weight by taking calories in excess of those required for maintenance. When weight is gained by normal increase in the intake of fat alone, there is a higher proportion of weight gained to calories ingested, and the weight gained may be maintained by an intake that is no greater than that required to maintain the initial weight. The chapter also describes the hormonal and circulating factors that affect the resistance to insulin in experimental obesity. It also presents evidence for cellular factors in resistance to insulin in experimental obesity and their response to gain in weight and to dietary carbohydrate." @default.
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- W197096040 date "1973-01-01" @default.
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- W197096040 title "Endocrine and Metabolic Effects of Experimental Obesity in Man" @default.
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- W197096040 doi "https://doi.org/10.1016/b978-0-12-571129-6.50016-6" @default.
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