Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970969924> ?p ?o ?g. }
- W1970969924 endingPage "618" @default.
- W1970969924 startingPage "607" @default.
- W1970969924 abstract "Loss of Bid confers clonogenic survival to granzyme B-treated cells, however the exact role of Bid-induced mitochondrial damage--upstream or downstream of caspases--remains controversial. Here we show that direct cleavage of Bid by granzyme B, but not caspases, was required for granzyme B-induced apoptosis. Release of cytochrome c and SMAC, but not AIF or endonuclease G, occurred in the absence of caspase activity and correlated with the onset of apoptosis and loss of clonogenic potential. Loss of mitochondrial trans-membrane potential (DeltaPsim) was also caspase independent, however if caspase activity was blocked the mitochondria regenerated their DeltaPsim. Loss of DeltaPsim was not required for rapid granzyme B-induced apoptosis and regeneration of DeltaPsim following cytochrome c release did not confer clonogenic survival. This functional dissociation of cytochrome c and SMAC release from loss of DeltaPsim demonstrates the essential contribution of Bid upstream of caspase activation during granzyme B-induced apoptosis." @default.
- W1970969924 created "2016-06-24" @default.
- W1970969924 creator A5020090786 @default.
- W1970969924 creator A5032896683 @default.
- W1970969924 creator A5035166515 @default.
- W1970969924 creator A5036417435 @default.
- W1970969924 creator A5037071541 @default.
- W1970969924 creator A5052829828 @default.
- W1970969924 creator A5061395547 @default.
- W1970969924 creator A5064189088 @default.
- W1970969924 creator A5075655484 @default.
- W1970969924 date "2005-09-16" @default.
- W1970969924 modified "2023-10-10" @default.
- W1970969924 title "Functional dissociation of ΔΨm and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis" @default.
- W1970969924 cites W1506642042 @default.
- W1970969924 cites W1586631084 @default.
- W1970969924 cites W1593219141 @default.
- W1970969924 cites W1961486822 @default.
- W1970969924 cites W1962843014 @default.
- W1970969924 cites W1972815935 @default.
- W1970969924 cites W1973109581 @default.
- W1970969924 cites W1973323097 @default.
- W1970969924 cites W1985521287 @default.
- W1970969924 cites W1987702938 @default.
- W1970969924 cites W1990098732 @default.
- W1970969924 cites W2005874504 @default.
- W1970969924 cites W2006981341 @default.
- W1970969924 cites W2007087244 @default.
- W1970969924 cites W2016170837 @default.
- W1970969924 cites W2020490276 @default.
- W1970969924 cites W2020670611 @default.
- W1970969924 cites W2026391442 @default.
- W1970969924 cites W2028319099 @default.
- W1970969924 cites W2031538453 @default.
- W1970969924 cites W2033380221 @default.
- W1970969924 cites W2042409437 @default.
- W1970969924 cites W2047394489 @default.
- W1970969924 cites W2048455227 @default.
- W1970969924 cites W2059573344 @default.
- W1970969924 cites W2075477970 @default.
- W1970969924 cites W2077626349 @default.
- W1970969924 cites W2083757029 @default.
- W1970969924 cites W2092818761 @default.
- W1970969924 cites W2098609440 @default.
- W1970969924 cites W2103699489 @default.
- W1970969924 cites W2110077740 @default.
- W1970969924 cites W2118731822 @default.
- W1970969924 cites W2135325091 @default.
- W1970969924 cites W2144951893 @default.
- W1970969924 cites W2158720649 @default.
- W1970969924 cites W2162653594 @default.
- W1970969924 cites W2166219468 @default.
- W1970969924 cites W2166291746 @default.
- W1970969924 cites W2170243414 @default.
- W1970969924 cites W2322040583 @default.
- W1970969924 doi "https://doi.org/10.1038/sj.cdd.4401772" @default.
- W1970969924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16167065" @default.
- W1970969924 hasPublicationYear "2005" @default.
- W1970969924 type Work @default.
- W1970969924 sameAs 1970969924 @default.
- W1970969924 citedByCount "51" @default.
- W1970969924 countsByYear W19709699242012 @default.
- W1970969924 countsByYear W19709699242013 @default.
- W1970969924 countsByYear W19709699242014 @default.
- W1970969924 countsByYear W19709699242015 @default.
- W1970969924 countsByYear W19709699242016 @default.
- W1970969924 countsByYear W19709699242019 @default.
- W1970969924 countsByYear W19709699242020 @default.
- W1970969924 countsByYear W19709699242021 @default.
- W1970969924 countsByYear W19709699242022 @default.
- W1970969924 countsByYear W19709699242023 @default.
- W1970969924 crossrefType "journal-article" @default.
- W1970969924 hasAuthorship W1970969924A5020090786 @default.
- W1970969924 hasAuthorship W1970969924A5032896683 @default.
- W1970969924 hasAuthorship W1970969924A5035166515 @default.
- W1970969924 hasAuthorship W1970969924A5036417435 @default.
- W1970969924 hasAuthorship W1970969924A5037071541 @default.
- W1970969924 hasAuthorship W1970969924A5052829828 @default.
- W1970969924 hasAuthorship W1970969924A5061395547 @default.
- W1970969924 hasAuthorship W1970969924A5064189088 @default.
- W1970969924 hasAuthorship W1970969924A5075655484 @default.
- W1970969924 hasBestOaLocation W19709699241 @default.
- W1970969924 hasConcept C154317977 @default.
- W1970969924 hasConcept C163421366 @default.
- W1970969924 hasConcept C183193105 @default.
- W1970969924 hasConcept C190283241 @default.
- W1970969924 hasConcept C202751555 @default.
- W1970969924 hasConcept C2775998712 @default.
- W1970969924 hasConcept C2776062744 @default.
- W1970969924 hasConcept C2780380082 @default.
- W1970969924 hasConcept C28859421 @default.
- W1970969924 hasConcept C29311851 @default.
- W1970969924 hasConcept C31573885 @default.
- W1970969924 hasConcept C55493867 @default.
- W1970969924 hasConcept C86803240 @default.
- W1970969924 hasConcept C91096171 @default.
- W1970969924 hasConcept C95444343 @default.
- W1970969924 hasConcept C98424977 @default.