Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970973190> ?p ?o ?g. }
- W1970973190 endingPage "39" @default.
- W1970973190 startingPage "29" @default.
- W1970973190 abstract "Antitumour efficacy of electroporated pEEV, coding for granulocyte-macrophage colony-stimulating factor and the B7-1 costimulatory immune molecule (pEEVGmCSF-b7.1) in growing solid tumours, was investigated and compared with a standard plasmid. Application of pEEVGmCSF-b7.1 led to complete tumour regression in 66% of CT26-treated tumours and 100% in the B16F10-treated tumours at day 150 post-treatment. pEEVGmCSF-b7.1 treatment was found to significantly enhance levels of both innate and adaptive immune populations in tumour and systemic sites, which corresponded to significantly increased tissue levels of proinflammatory cytokines including interferon-γ (IFN-γ) and interleukin-12 (IL-12). In contrast, pEEVGmCSF-b7.1 treatment significantly reduced the T-regulatory populations and also the anti-inflammatory cytokine IL-10. Upon further characterisation of functional immune responses, we observed a significant increase in cytotoxic (CD107a+) and IFN-γ-producing natural killer cells and also significantly more in IL-12-producing B cells. Importantly, splenocytes isolated from pEEVGmCSF-b7.1-treated 'cured' mice were tumour-specific and afforded significant protection in a tumour rechallenge model (Winn assay). Our data indicate that electroimmunogene therapy with the non-viral pEEVGmCSF-b7.1 is able to induce potent and durable antitumour immune responses that significantly reduce primary and also secondary tumour growth, and thus represents a solid therapeutic platform for pursuing future clinical trials." @default.
- W1970973190 created "2016-06-24" @default.
- W1970973190 creator A5005875083 @default.
- W1970973190 creator A5031912866 @default.
- W1970973190 creator A5043520587 @default.
- W1970973190 creator A5048928273 @default.
- W1970973190 creator A5062974235 @default.
- W1970973190 creator A5069431887 @default.
- W1970973190 creator A5069547987 @default.
- W1970973190 date "2014-11-06" @default.
- W1970973190 modified "2023-09-27" @default.
- W1970973190 title "Non-viral immune electrogene therapy induces potent antitumour responses and has a curative effect in murine colon adenocarcinoma and melanoma cancer models" @default.
- W1970973190 cites W1542537947 @default.
- W1970973190 cites W1571520647 @default.
- W1970973190 cites W1576029512 @default.
- W1970973190 cites W1861388616 @default.
- W1970973190 cites W1972913617 @default.
- W1970973190 cites W1976820932 @default.
- W1970973190 cites W1976899534 @default.
- W1970973190 cites W1987113274 @default.
- W1970973190 cites W1991748190 @default.
- W1970973190 cites W1992472131 @default.
- W1970973190 cites W2012990707 @default.
- W1970973190 cites W2014356856 @default.
- W1970973190 cites W2016508818 @default.
- W1970973190 cites W2018449740 @default.
- W1970973190 cites W2020026758 @default.
- W1970973190 cites W2023902508 @default.
- W1970973190 cites W2023931342 @default.
- W1970973190 cites W2028587641 @default.
- W1970973190 cites W2037127090 @default.
- W1970973190 cites W2053525254 @default.
- W1970973190 cites W2061297246 @default.
- W1970973190 cites W2065946404 @default.
- W1970973190 cites W2067203011 @default.
- W1970973190 cites W2074850513 @default.
- W1970973190 cites W2075556466 @default.
- W1970973190 cites W2077850392 @default.
- W1970973190 cites W2078023230 @default.
- W1970973190 cites W2078352032 @default.
- W1970973190 cites W2081644109 @default.
- W1970973190 cites W2084652077 @default.
- W1970973190 cites W2100669312 @default.
- W1970973190 cites W2101771134 @default.
- W1970973190 cites W2122387392 @default.
- W1970973190 cites W2124095998 @default.
- W1970973190 cites W2125837906 @default.
- W1970973190 cites W2130290528 @default.
- W1970973190 cites W2146313292 @default.
- W1970973190 cites W2155673686 @default.
- W1970973190 cites W2167619535 @default.
- W1970973190 cites W2313751154 @default.
- W1970973190 cites W2326434797 @default.
- W1970973190 doi "https://doi.org/10.1038/gt.2014.95" @default.
- W1970973190 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4289754" @default.
- W1970973190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25373914" @default.
- W1970973190 hasPublicationYear "2014" @default.
- W1970973190 type Work @default.
- W1970973190 sameAs 1970973190 @default.
- W1970973190 citedByCount "5" @default.
- W1970973190 countsByYear W19709731902016 @default.
- W1970973190 countsByYear W19709731902017 @default.
- W1970973190 countsByYear W19709731902022 @default.
- W1970973190 crossrefType "journal-article" @default.
- W1970973190 hasAuthorship W1970973190A5005875083 @default.
- W1970973190 hasAuthorship W1970973190A5031912866 @default.
- W1970973190 hasAuthorship W1970973190A5043520587 @default.
- W1970973190 hasAuthorship W1970973190A5048928273 @default.
- W1970973190 hasAuthorship W1970973190A5062974235 @default.
- W1970973190 hasAuthorship W1970973190A5069431887 @default.
- W1970973190 hasAuthorship W1970973190A5069547987 @default.
- W1970973190 hasBestOaLocation W19709731901 @default.
- W1970973190 hasConcept C154317977 @default.
- W1970973190 hasConcept C164027704 @default.
- W1970973190 hasConcept C202751555 @default.
- W1970973190 hasConcept C203014093 @default.
- W1970973190 hasConcept C2776178377 @default.
- W1970973190 hasConcept C2776914184 @default.
- W1970973190 hasConcept C2777658100 @default.
- W1970973190 hasConcept C2777701055 @default.
- W1970973190 hasConcept C2778690821 @default.
- W1970973190 hasConcept C502942594 @default.
- W1970973190 hasConcept C55493867 @default.
- W1970973190 hasConcept C86803240 @default.
- W1970973190 hasConcept C8891405 @default.
- W1970973190 hasConceptScore W1970973190C154317977 @default.
- W1970973190 hasConceptScore W1970973190C164027704 @default.
- W1970973190 hasConceptScore W1970973190C202751555 @default.
- W1970973190 hasConceptScore W1970973190C203014093 @default.
- W1970973190 hasConceptScore W1970973190C2776178377 @default.
- W1970973190 hasConceptScore W1970973190C2776914184 @default.
- W1970973190 hasConceptScore W1970973190C2777658100 @default.
- W1970973190 hasConceptScore W1970973190C2777701055 @default.
- W1970973190 hasConceptScore W1970973190C2778690821 @default.
- W1970973190 hasConceptScore W1970973190C502942594 @default.
- W1970973190 hasConceptScore W1970973190C55493867 @default.
- W1970973190 hasConceptScore W1970973190C86803240 @default.
- W1970973190 hasConceptScore W1970973190C8891405 @default.