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• W1970978131 abstract "Modulation of serotonin signaling by RNA editing of the serotonin 2C receptor (5HT2CR) may be relevant to affective disorder as serotonin functions regulate mood and behavior. Previously, we observed enhanced endogenous behavioral despair in ADAR2 transgenic mice. As the transcript of the 5HT2CR is a substrate of ADAR2, we hypothesized that perturbed ADAR2 equilibrium in the prefrontal cortex of ADAR2 transgenic mice alters the normal distribution of edited amino acid isoforms of the 5HT2CR and modifies the receptor function in downstream basal extracellular signal-regulated kinase (ERK) signaling. We examined groups of naive control and ADAR2 transgenic mice and found significantly increased ADAR2 expression, increased RNA editing at A, C, D and E sites and significantly altered normal distribution of edited amino acid isoforms of the 5HT2CR with increased proportions of valine asparagine valine, valine serine valine, valine asparagine isoleucine, isoleucine asparagine valine and decreased isoleucine asparagine isoleucine amino acid isoforms of the 5HT2CR in ADAR2 transgenic mice. Localized serotonin levels (5-HT) were unchanged and perturbed ADAR2 equilibrium coincides with dysregulated edited amino acid isoforms of the 5HT2CR and reduced basal ERK signaling. These results altogether suggest that altered 5HT2CR function could be contributing to enhanced depression-like behavior of ADAR2 transgenic mice and further implicate ADAR2 as a contributing factor in cases of affective disorder." @default.
• W1970978131 created "2016-06-24" @default.
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• W1970978131 date "2011-06-13" @default.
• W1970978131 modified "2023-10-17" @default.
• W1970978131 title "Altered ADAR 2 equilibrium and 5HT2CR editing in the prefrontal cortex of ADAR 2 transgenic mice" @default.
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• W1970978131 doi "https://doi.org/10.1111/j.1601-183x.2011.00701.x" @default.
• W1970978131 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3150620" @default.
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