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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970981504> ?p ?o ?g. }

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• W1970981504 abstract "Here we report a proof-of-principle study demonstrating the efficient folding, with concomitant formation of the correct disulfides, of an isolated polypeptide insulin precursor of defined covalent structure. We used oxime-forming chemical ligation to introduce a temporary chemical tether to link the N-terminal residue of the insulin A chain to the C-terminal residue of the insulin B chain; the tether enabled us to fold/form disulfides with high efficiency. Enzymatic removal of the temporary chemical tether gave mature, fully active insulin. This chemical tethering principle could form the basis of a practical, high yield total synthesis of insulin and analogues." @default.
• W1970981504 created "2016-06-24" @default.
• W1970981504 creator A5020861873 @default.
• W1970981504 creator A5024175774 @default.
• W1970981504 date "2009-10-16" @default.
• W1970981504 modified "2023-09-23" @default.
• W1970981504 title "Biomimetic Synthesis of Lispro Insulin via a Chemically Synthesized “Mini-Proinsulin” Prepared by Oxime-Forming Ligation" @default.
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• W1970981504 doi "https://doi.org/10.1021/ja9052398" @default.
• W1970981504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3690821" @default.
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