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- W1970985364 abstract "In Reply.— The rationale behind the synchronization concept of plasmapheresis with subsequent pulse cyclophosphamide therapy is to utilize the increased vulnerability of pathogenic B cells by applying high-dose cytotoxic drugs shortly after antibody depletion during the period of maximum antibody rebound, ie, during the period of maximum depletion-induced B-cell proliferation and vulnerability. This basic concept was applied experimentally as early as 1971.1It was first applied clinically in myasthenia gravis in 1980,2in systemic lupus erythematosus in 1981,3and in Goodpasture's syndrome in 1982.4It was suggested for severe pemphigus5in 1983, and it was first applied clinically in pemphigus vulgaris in one of seven briefly reported cases in a 1984 article by Ruocco and coworkers.6We regret that none of us had seen that article. However, though the basic rationale is the same as in our report,7there are some major differences concerning the strictness" @default.
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- W1970985364 date "1988-11-01" @default.
- W1970985364 modified "2023-10-05" @default.
- W1970985364 title "Plasmapheresis and Pulse Cyclophosphamide Therapy in Pemphigus Vulgaris: A Novelty or a Reappraisal?-Reply" @default.
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- W1970985364 doi "https://doi.org/10.1001/archderm.1988.01670110073019" @default.
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