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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970986374> ?p ?o ?g. }

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• W1970986374 abstract "We have identified and synthesized a series of 4-thiopyridyl acetophenones as positive allosteric potentiators of the metabotropic glutamate receptor 2. Structure-activity relationship studies directed toward replacement of the tetrazole in the initial lead led to the discovery of 16 (EC(50)=340 nM), which showed improved brain penetration over the initial lead." @default.
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• W1970986374 date "2004-12-01" @default.
• W1970986374 modified "2023-10-13" @default.
• W1970986374 title "Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 2: 4-Thiopyridyl acetophenones as non-tetrazole containing mGlu2 receptor potentiators" @default.
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• W1970986374 doi "https://doi.org/10.1016/j.bmcl.2004.09.028" @default.
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