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- W1970996716 abstract "Morphogenesis and biochemical differentiation of the female breast in vivo is regulated by a complex of hormones required at different stages of development. This is emphasized by the alveolar epithelial component during lactation, which represents a highly organized group of cells specifically differentiated under the influence of a number of hormones produced by the ovary, pituitary, and pancreas. The ovarian hormones include estrogen and progesterone; the pituitary provides prolactin and/or somatotropin; and the presumed requirement of insulin is provided by the pancreas.Depending on the stage of duct and alveolar development, it is possible to identify some of the phases of hormone induction as: (1) an inactive resting phase, (2) a proliferative phase as pregnancy proceeds, (3) an active lactation phase immediately following pregnancy, (4) a postnatal regressive change with minor alterations evident during menses, and finally (5) a menopausal atrophy of the glandular tissue.Experimental studies of mammogenesis in the mouse suggest that stages up to the 7th day of fetal life are independent of specific hormones required for development." @default.
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- W1970996716 date "1960-06-01" @default.
- W1970996716 modified "2023-10-18" @default.
- W1970996716 title "Development of alveoli in organ cultures of total mammary glands of six weeks old virgin mice" @default.
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- W1970996716 doi "https://doi.org/10.1016/0014-4827(60)90254-8" @default.
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