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• W1970997910 abstract "Abstract Metabolic modeling of 13 C NMR spectroscopy ( 13 C MRS) data using two‐compartment neuronal‐glial models enabled non‐invasive measurements of the glutamate‐glutamine cycle rate (V NT ) in the brain in vivo. However, the reliability of such two‐compartment metabolic modeling has not been examined thoroughly. This study uses Monte‐Carlo simulations to investigate the reliability of metabolic modeling of 13 C positional enrichment time courses measured in brain amino acids such as glutamate and glutamine during [1‐ 13 C]‐ or [1,6‐ 13 C 2 ]glucose infusion. Results show that the determination of V NT is not very precise under experimental conditions typical of in vivo NMR studies, whereas the neuronal TCA cycle rate V TCA(N) is determined with a much higher precision. Consistent with these results, simulated 13 C positional enrichment curves for glutamate and glutamine are much more sensitive to the value of V TCA(N) than to the value of V NT . We conclude that the determination of the glutamate‐glutamine cycle rate V NT using 13 C MRS is relatively unreliable when fitting 13 C positional enrichment curves obtained during [1‐ 13 C] or [1,6‐ 13 C 2 ]glucose infusion. Further developments are needed to improve the determination of V NT , for example using additional information from 13 C‐ 13 C isotopomers and/or using glial specific substrates such as [2‐ 13 C]acetate. © 2007 Wiley‐Liss, Inc." @default.
• W1970997910 created "2016-06-24" @default.
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• W1970997910 date "2007-03-28" @default.
• W1970997910 modified "2023-10-12" @default.
• W1970997910 title "On the reliability of ¹³C metabolic modeling with two‐compartment neuronal‐glial models" @default.
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• W1970997910 doi "https://doi.org/10.1002/jnr.21269" @default.
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