FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970999387> ?p ?o ?g. }

• W1970999387 endingPage "2287" @default.
• W1970999387 startingPage "2274" @default.
• W1970999387 abstract "Although a number of studies have been conducted to address the relation between a gene deletion polymorphism of glutathione S-transferase M1 (GSTM1) and breast cancer, no definite conclusion has been reached and no clear risk pattern has yet to emerge for GSTM1. We first conducted case-control studies that included 1920 subjects using a genotyping method allowing the definition of GSTM1-null (-/-), homozygous wild-type (+/+), and heterozygous (+/-) genotypes. The results show that GSTM1(-/-) confers an increased risk for breast cancer development compared with that in GSTM1-present individuals (+/+ and +/-), which was subsequently confirmed by a meta-analysis of all of the 41 relevant studies (odds ratio: 1.10, P<0.001). Unexpectedly, we found that GSTM1(+/+) is also a risk genotype compared with GSTM1(+/-). Furthermore, we identified a functional polymorphism in the GSTM1 promoter region associated with breast cancer. The variant allele modifies DNA binding to the AP-2alpha transcription factor, resulting in reduced promoter activity and mRNA expression. However, this low-activity allele is associated with reduced breast cancer risk. It seems that approximately 60-70% expression from one allele of GSTM1 could suffice for protection against breast cancer; null activity and overactivity of GSTM1 are both disadvantageous. These results indicate a U-shaped association of GSTM1 with breast cancer, which challenges the linear gene-dosage effect of GSTM1 that was previously proposed. We recommend that a more complicated role for GSTM1 should be considered in breast cancer risk prediction." @default.
• W1970999387 created "2016-06-24" @default.
• W1970999387 creator A5000980489 @default.
• W1970999387 creator A5003928622 @default.
• W1970999387 creator A5010345121 @default.
• W1970999387 creator A5020804276 @default.
• W1970999387 creator A5022412860 @default.
• W1970999387 creator A5024671609 @default.
• W1970999387 creator A5031724124 @default.
• W1970999387 creator A5058743657 @default.
• W1970999387 date "2009-02-19" @default.
• W1970999387 modified "2023-10-16" @default.
• W1970999387 title "A functional polymorphism in the promoter region of<i>GSTM1</i>implies a complex role for<i>GSTM1</i>in breast cancer" @default.
• W1970999387 cites W1605085650 @default.
• W1970999387 cites W1753058125 @default.
• W1970999387 cites W1965192399 @default.
• W1970999387 cites W1973275034 @default.
• W1970999387 cites W1978428628 @default.
• W1970999387 cites W1983078946 @default.
• W1970999387 cites W1993214904 @default.
• W1970999387 cites W2026212709 @default.
• W1970999387 cites W2028691872 @default.
• W1970999387 cites W2049828760 @default.
• W1970999387 cites W2052572594 @default.
• W1970999387 cites W2054610155 @default.
• W1970999387 cites W2055449612 @default.
• W1970999387 cites W2055489824 @default.
• W1970999387 cites W2061539831 @default.
• W1970999387 cites W2067303354 @default.
• W1970999387 cites W2073123124 @default.
• W1970999387 cites W2074724288 @default.
• W1970999387 cites W2079386626 @default.
• W1970999387 cites W2086787632 @default.
• W1970999387 cites W2089264078 @default.
• W1970999387 cites W2091626808 @default.
• W1970999387 cites W2107887211 @default.
• W1970999387 cites W2108244474 @default.
• W1970999387 cites W2112365969 @default.
• W1970999387 cites W2131253649 @default.
• W1970999387 cites W2152664025 @default.
• W1970999387 cites W2153309340 @default.
• W1970999387 cites W2159228883 @default.
• W1970999387 cites W2167108935 @default.
• W1970999387 cites W2168251468 @default.
• W1970999387 cites W2174879024 @default.
• W1970999387 cites W2181909974 @default.
• W1970999387 cites W2399974113 @default.
• W1970999387 cites W2407955315 @default.
• W1970999387 doi "https://doi.org/10.1096/fj.08-124073" @default.
• W1970999387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19228880" @default.
• W1970999387 hasPublicationYear "2009" @default.
• W1970999387 type Work @default.
• W1970999387 sameAs 1970999387 @default.
• W1970999387 citedByCount "46" @default.
• W1970999387 countsByYear W19709993872012 @default.
• W1970999387 countsByYear W19709993872013 @default.
• W1970999387 countsByYear W19709993872015 @default.
• W1970999387 countsByYear W19709993872016 @default.
• W1970999387 countsByYear W19709993872017 @default.
• W1970999387 countsByYear W19709993872018 @default.
• W1970999387 countsByYear W19709993872020 @default.
• W1970999387 countsByYear W19709993872021 @default.
• W1970999387 countsByYear W19709993872022 @default.
• W1970999387 crossrefType "journal-article" @default.
• W1970999387 hasAuthorship W1970999387A5000980489 @default.
• W1970999387 hasAuthorship W1970999387A5003928622 @default.
• W1970999387 hasAuthorship W1970999387A5010345121 @default.
• W1970999387 hasAuthorship W1970999387A5020804276 @default.
• W1970999387 hasAuthorship W1970999387A5022412860 @default.
• W1970999387 hasAuthorship W1970999387A5024671609 @default.
• W1970999387 hasAuthorship W1970999387A5031724124 @default.
• W1970999387 hasAuthorship W1970999387A5058743657 @default.
• W1970999387 hasConcept C101762097 @default.
• W1970999387 hasConcept C104317684 @default.
• W1970999387 hasConcept C121608353 @default.
• W1970999387 hasConcept C126322002 @default.
• W1970999387 hasConcept C135763542 @default.
• W1970999387 hasConcept C143998085 @default.
• W1970999387 hasConcept C150194340 @default.
• W1970999387 hasConcept C156957248 @default.
• W1970999387 hasConcept C180754005 @default.
• W1970999387 hasConcept C31467283 @default.
• W1970999387 hasConcept C530470458 @default.
• W1970999387 hasConcept C54355233 @default.
• W1970999387 hasConcept C71924100 @default.
• W1970999387 hasConcept C86803240 @default.
• W1970999387 hasConceptScore W1970999387C101762097 @default.
• W1970999387 hasConceptScore W1970999387C104317684 @default.
• W1970999387 hasConceptScore W1970999387C121608353 @default.
• W1970999387 hasConceptScore W1970999387C126322002 @default.
• W1970999387 hasConceptScore W1970999387C135763542 @default.
• W1970999387 hasConceptScore W1970999387C143998085 @default.
• W1970999387 hasConceptScore W1970999387C150194340 @default.
• W1970999387 hasConceptScore W1970999387C156957248 @default.
• W1970999387 hasConceptScore W1970999387C180754005 @default.
• W1970999387 hasConceptScore W1970999387C31467283 @default.
• W1970999387 hasConceptScore W1970999387C530470458 @default.
• W1970999387 hasConceptScore W1970999387C54355233 @default.

• next