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• W1971004772 abstract "Dentate gyrus (DG) neurogenesis is transiently increased during the first weeks after status epilepticus (SE). Survival of the new neurons is initially compromised by an acute inflammatory response, but the long-term fate of the remaining ones in the post-SE environment is unknown. Here adult rats were subjected to 2 h electrically evoked self-sustained SE and perfused after 5 weeks or 6 months. Rats exhibited partial or generalized SE followed by spontaneous behavioural seizures and abnormal electroencephalographic activity during 6 months. Numbers of activated microglia in the dentate subgranular zone (SGZ)-granule cell layer (GCL) and in the hilus declined after 5 weeks, but were still elevated at 6 months after SE, with no differences between the milder partial and the more severe generalized SE. At 6 months, partial and generalized SE rats showed a seven-fold increase in the number of mature SGZ–GCL neurons formed during the first 2 weeks along with aberrant neurons in the hilus. Total numbers of mature neurons in SGZ–GCL were unaltered, indicating that SE-generated neurons replaced dead granule cells. Neuroblast formation had returned to normal levels in SGZ–GCL but generation of aberrant neurons in the hilus was still ongoing at 6 months. Our data indicate that long-term impairment of neurogenesis, as reported previously after kainic acid-induced SE, is not a general feature of chronic epilepsy. We have found that a substantial proportion of the mature granule cells at 6 months are generated during the first 2 weeks after SE and survive despite chronic inflammation, and that SE triggers continuous production of aberrant hilar neurons." @default.
• W1971004772 created "2016-06-24" @default.
• W1971004772 creator A5012111660 @default.
• W1971004772 creator A5046090769 @default.
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• W1971004772 date "2006-02-01" @default.
• W1971004772 modified "2023-09-27" @default.
• W1971004772 title "Long-term neuronal replacement in adult rat hippocampus after status epilepticus despite chronic inflammation" @default.
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• W1971004772 doi "https://doi.org/10.1111/j.1460-9568.2006.04635.x" @default.
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