Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971010914> ?p ?o ?g. }
- W1971010914 abstract "CTGF is a secreted matricellular protein with very complex biology. It has been shown to modulate many signaling pathways leading to cell adhesion and migration, angiogenesis, myofibroblast activation, and extracellular matrix deposition and remodeling, which together lead to tissue remodeling and fibrosis. It has been reported in the literature that inhibition of CTGF expression by siRNA prevents CCl4-induced liver fibrosis and can reverse fibrosis when administered after significant collagen deposition is observed. A monoclonal antibody to CTGF that is currently in clinical development (FG-3019) has demonstrated the ability to reverse vascular stiffening and improve cardiac function in a rat model of diabetic complications. FG-3019 has also exhibited activity in a murine radiation-induced pulmonary fibrosis model. When FG-3019 was administered to mice after a significant radiation-induced increase in lung density could be observed by CT imaging, the density of the lungs was observed to decrease over the period during which the antibody was administered and to remain stable after therapy had ceased. When considered together, these data indicate that inhibition of CTGF can prevent and reverse the process of fibrosis." @default.
- W1971010914 created "2016-06-24" @default.
- W1971010914 creator A5052995487 @default.
- W1971010914 creator A5055296814 @default.
- W1971010914 creator A5073316865 @default.
- W1971010914 creator A5089482204 @default.
- W1971010914 date "2012-06-06" @default.
- W1971010914 modified "2023-10-09" @default.
- W1971010914 title "CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis" @default.
- W1971010914 cites W1539004296 @default.
- W1971010914 cites W1964199332 @default.
- W1971010914 cites W1967236086 @default.
- W1971010914 cites W1971318940 @default.
- W1971010914 cites W1975085088 @default.
- W1971010914 cites W1976599453 @default.
- W1971010914 cites W1982333741 @default.
- W1971010914 cites W1982830057 @default.
- W1971010914 cites W1984841510 @default.
- W1971010914 cites W1986575842 @default.
- W1971010914 cites W1998214223 @default.
- W1971010914 cites W2001494285 @default.
- W1971010914 cites W2001690919 @default.
- W1971010914 cites W2014244822 @default.
- W1971010914 cites W2044001497 @default.
- W1971010914 cites W2053865773 @default.
- W1971010914 cites W2057686826 @default.
- W1971010914 cites W2063695842 @default.
- W1971010914 cites W2064757398 @default.
- W1971010914 cites W2067645178 @default.
- W1971010914 cites W2070774527 @default.
- W1971010914 cites W2075078693 @default.
- W1971010914 cites W2083544543 @default.
- W1971010914 cites W2085779076 @default.
- W1971010914 cites W2087027548 @default.
- W1971010914 cites W2087920840 @default.
- W1971010914 cites W2109974825 @default.
- W1971010914 cites W2110898038 @default.
- W1971010914 cites W2111630252 @default.
- W1971010914 cites W2112302625 @default.
- W1971010914 cites W2116323280 @default.
- W1971010914 cites W2122742138 @default.
- W1971010914 cites W2128421976 @default.
- W1971010914 cites W2132445818 @default.
- W1971010914 cites W2142799375 @default.
- W1971010914 cites W2146350838 @default.
- W1971010914 cites W2148118059 @default.
- W1971010914 cites W2149449623 @default.
- W1971010914 cites W2156553323 @default.
- W1971010914 cites W2162424291 @default.
- W1971010914 cites W2165568231 @default.
- W1971010914 cites W2169804478 @default.
- W1971010914 cites W323639349 @default.
- W1971010914 cites W4234944895 @default.
- W1971010914 cites W4235484022 @default.
- W1971010914 cites W4251796875 @default.
- W1971010914 doi "https://doi.org/10.1186/1755-1536-5-s1-s24" @default.
- W1971010914 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3368796" @default.
- W1971010914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23259531" @default.
- W1971010914 hasPublicationYear "2012" @default.
- W1971010914 type Work @default.
- W1971010914 sameAs 1971010914 @default.
- W1971010914 citedByCount "421" @default.
- W1971010914 countsByYear W19710109142013 @default.
- W1971010914 countsByYear W19710109142014 @default.
- W1971010914 countsByYear W19710109142015 @default.
- W1971010914 countsByYear W19710109142016 @default.
- W1971010914 countsByYear W19710109142017 @default.
- W1971010914 countsByYear W19710109142018 @default.
- W1971010914 countsByYear W19710109142019 @default.
- W1971010914 countsByYear W19710109142020 @default.
- W1971010914 countsByYear W19710109142021 @default.
- W1971010914 countsByYear W19710109142022 @default.
- W1971010914 countsByYear W19710109142023 @default.
- W1971010914 crossrefType "journal-article" @default.
- W1971010914 hasAuthorship W1971010914A5052995487 @default.
- W1971010914 hasAuthorship W1971010914A5055296814 @default.
- W1971010914 hasAuthorship W1971010914A5073316865 @default.
- W1971010914 hasAuthorship W1971010914A5089482204 @default.
- W1971010914 hasBestOaLocation W19710109141 @default.
- W1971010914 hasConcept C126322002 @default.
- W1971010914 hasConcept C142724271 @default.
- W1971010914 hasConcept C170493617 @default.
- W1971010914 hasConcept C189165786 @default.
- W1971010914 hasConcept C207865475 @default.
- W1971010914 hasConcept C2775893135 @default.
- W1971010914 hasConcept C2775960820 @default.
- W1971010914 hasConcept C2780394083 @default.
- W1971010914 hasConcept C2780559512 @default.
- W1971010914 hasConcept C2780631158 @default.
- W1971010914 hasConcept C2781244666 @default.
- W1971010914 hasConcept C502942594 @default.
- W1971010914 hasConcept C71924100 @default.
- W1971010914 hasConcept C86803240 @default.
- W1971010914 hasConcept C95444343 @default.
- W1971010914 hasConceptScore W1971010914C126322002 @default.
- W1971010914 hasConceptScore W1971010914C142724271 @default.
- W1971010914 hasConceptScore W1971010914C170493617 @default.
- W1971010914 hasConceptScore W1971010914C189165786 @default.
- W1971010914 hasConceptScore W1971010914C207865475 @default.
- W1971010914 hasConceptScore W1971010914C2775893135 @default.