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• W1971012331 endingPage "918" @default.
• W1971012331 startingPage "910" @default.
• W1971012331 abstract "This study aimed to identify the cortical mechanisms underlying the processes of interictal dishabituation to experimental pain in subjects suffering from migraine with aura (MWA). In 21 subjects with MWA and 22 healthy controls, cortical responses to two successive trials of noxious contact-heat stimuli were analyzed using EEG-tomography software. When compared with controls, MWA patients showed significantly increased pain-evoked potential amplitudes accompanied by reduced activity in the orbitofrontal cortex (OFC) and increased activity in the pain matrix regions, including the primary somatosensory cortex (SI) ( p < .05). Similarly to controls, MWA subjects displayed an inverse correlation between the OFC and SI activities, and positive interrelations between other pain-specific regions. The activity changes in the OFC negatively correlated with lifetime headache duration and longevity ( p < .05). Reduced inhibitory functioning of the prefrontal cortex is a possible cause for disinhibition of the pain-related sensory cortices in migraine. The finding of OFC hypofunction over the disease course is in keeping with current concepts of migraine as a progressive brain disorder." @default.
• W1971012331 created "2016-06-24" @default.
• W1971012331 creator A5012480460 @default.
• W1971012331 creator A5043240900 @default.
• W1971012331 creator A5054716824 @default.
• W1971012331 date "2010-03-12" @default.
• W1971012331 modified "2023-10-18" @default.
• W1971012331 title "Orbitofrontal disinhibition of pain in migraine with aura: An interictal EEG-mapping study" @default.
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• W1971012331 doi "https://doi.org/10.1177/0333102409357249" @default.
• W1971012331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20656702" @default.
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