Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971020007> ?p ?o ?g. }
- W1971020007 endingPage "144" @default.
- W1971020007 startingPage "139" @default.
- W1971020007 abstract "We report that the antimalarial drug artemisinin inhibits hepatitis C virus (HCV) replicon replication in a dose-dependent manner in two replicon constructs at concentrations that have no effect on the proliferation of the exponentially growing host cells. The 50% effective concentration (EC50) for inhibition of HCV subgenomic replicon replication in Huh 5-2 cells (luciferase assay) by artemisinin was 78 ± 21 μM. Hemin, an iron donor, was recently reported to inhibit HCV replicon replication [mediated by inhibition of the viral polymerase (C. Fillebeen, A.M. Rivas-Estilla, M. Bisaillon, P. Ponka, M. Muckenthaler, M.W. Hentze, A.E. Koromilas, K. Pantopoulos, Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C virus, J. Biol. Chem. 280 (2005) 9049–9057.)] at a concentration that had no adverse effect on the host cells. When combined, artemisinin and hemin resulted, over a broad concentration range, in a pronounced synergistic antiviral activity. Also at a concentration (2 μM) that alone had no effect on HCV replication, hemin still potentiated the anti-HCV activity of artemisinin." @default.
- W1971020007 created "2016-06-24" @default.
- W1971020007 creator A5008713330 @default.
- W1971020007 creator A5021298063 @default.
- W1971020007 creator A5022319088 @default.
- W1971020007 creator A5040662398 @default.
- W1971020007 creator A5040962582 @default.
- W1971020007 creator A5047901956 @default.
- W1971020007 creator A5052667034 @default.
- W1971020007 creator A5056476810 @default.
- W1971020007 creator A5089010495 @default.
- W1971020007 date "2006-09-01" @default.
- W1971020007 modified "2023-10-18" @default.
- W1971020007 title "Hemin potentiates the anti-hepatitis C virus activity of the antimalarial drug artemisinin" @default.
- W1971020007 cites W1969451624 @default.
- W1971020007 cites W1970605250 @default.
- W1971020007 cites W1975077708 @default.
- W1971020007 cites W1987306816 @default.
- W1971020007 cites W2012698685 @default.
- W1971020007 cites W2014895979 @default.
- W1971020007 cites W2015823022 @default.
- W1971020007 cites W2033721665 @default.
- W1971020007 cites W2035784901 @default.
- W1971020007 cites W2054174404 @default.
- W1971020007 cites W2061941938 @default.
- W1971020007 cites W2069531923 @default.
- W1971020007 cites W2073385105 @default.
- W1971020007 cites W2075095707 @default.
- W1971020007 cites W2080543752 @default.
- W1971020007 cites W2082933842 @default.
- W1971020007 cites W2083634651 @default.
- W1971020007 cites W2086891449 @default.
- W1971020007 cites W2095199759 @default.
- W1971020007 cites W2097913517 @default.
- W1971020007 cites W2098184601 @default.
- W1971020007 cites W2102383058 @default.
- W1971020007 cites W2106239124 @default.
- W1971020007 cites W2108523194 @default.
- W1971020007 cites W2111736586 @default.
- W1971020007 cites W2136523601 @default.
- W1971020007 cites W2139878820 @default.
- W1971020007 cites W2142777712 @default.
- W1971020007 cites W2148976224 @default.
- W1971020007 cites W2150368001 @default.
- W1971020007 cites W2151898297 @default.
- W1971020007 cites W2165260654 @default.
- W1971020007 cites W2168586962 @default.
- W1971020007 cites W2792087431 @default.
- W1971020007 doi "https://doi.org/10.1016/j.bbrc.2006.07.014" @default.
- W1971020007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16875675" @default.
- W1971020007 hasPublicationYear "2006" @default.
- W1971020007 type Work @default.
- W1971020007 sameAs 1971020007 @default.
- W1971020007 citedByCount "61" @default.
- W1971020007 countsByYear W19710200072013 @default.
- W1971020007 countsByYear W19710200072014 @default.
- W1971020007 countsByYear W19710200072015 @default.
- W1971020007 countsByYear W19710200072016 @default.
- W1971020007 countsByYear W19710200072017 @default.
- W1971020007 countsByYear W19710200072018 @default.
- W1971020007 countsByYear W19710200072019 @default.
- W1971020007 countsByYear W19710200072020 @default.
- W1971020007 countsByYear W19710200072021 @default.
- W1971020007 countsByYear W19710200072022 @default.
- W1971020007 countsByYear W19710200072023 @default.
- W1971020007 crossrefType "journal-article" @default.
- W1971020007 hasAuthorship W1971020007A5008713330 @default.
- W1971020007 hasAuthorship W1971020007A5021298063 @default.
- W1971020007 hasAuthorship W1971020007A5022319088 @default.
- W1971020007 hasAuthorship W1971020007A5040662398 @default.
- W1971020007 hasAuthorship W1971020007A5040962582 @default.
- W1971020007 hasAuthorship W1971020007A5047901956 @default.
- W1971020007 hasAuthorship W1971020007A5052667034 @default.
- W1971020007 hasAuthorship W1971020007A5056476810 @default.
- W1971020007 hasAuthorship W1971020007A5089010495 @default.
- W1971020007 hasConcept C104317684 @default.
- W1971020007 hasConcept C140704245 @default.
- W1971020007 hasConcept C153911025 @default.
- W1971020007 hasConcept C159047783 @default.
- W1971020007 hasConcept C18103114 @default.
- W1971020007 hasConcept C181199279 @default.
- W1971020007 hasConcept C185592680 @default.
- W1971020007 hasConcept C189819185 @default.
- W1971020007 hasConcept C203014093 @default.
- W1971020007 hasConcept C22744801 @default.
- W1971020007 hasConcept C2522874641 @default.
- W1971020007 hasConcept C2776120307 @default.
- W1971020007 hasConcept C2776217839 @default.
- W1971020007 hasConcept C2776408679 @default.
- W1971020007 hasConcept C2777723881 @default.
- W1971020007 hasConcept C2778048844 @default.
- W1971020007 hasConcept C2778371730 @default.
- W1971020007 hasConcept C2781426373 @default.
- W1971020007 hasConcept C2781463415 @default.
- W1971020007 hasConcept C55493867 @default.
- W1971020007 hasConcept C67705224 @default.
- W1971020007 hasConcept C86803240 @default.
- W1971020007 hasConceptScore W1971020007C104317684 @default.