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• W1971021330 startingPage "2770" @default.
• W1971021330 abstract "We used patch-clamp recordings and fast optical Ca 2+ imaging to characterize an acetylcholine-induced current ( I ACh ) in leg motoneurons of the stick insect Carausius morosus. Our long-term goal is to better understand the synaptic and integrative properties of the leg sensory-motor system, which has served extremely successfully as a model to study basic principles of walking and locomotion on the network level. The experiments were performed under biophysically controlled conditions on freshly dissociated leg motoneurons to avoid secondary effects from the network. To allow for unequivocal identification, the leg motoneurons were backfilled with a fluorescent label through the main leg nerve prior to cell dissociation. In 87% of the motoneurons, I ACh consisted of a fast-desensitizing ( I ACh1 ) and a slow-desensitizing component ( I ACh2 ), both of which were concentration dependent, with EC 50 values of 3.7 × 10 −5 and 2.0 × 10 −5 M, respectively. Ca 2+ imaging revealed that a considerable portion of I ACh (∼18%) is carried by Ca 2+ , suggesting that I ACh , besides mediating fast synaptic transmission, could also induce Ca 2+ -dependent processes. Using specific nicotinic and muscarinic acetylcholine receptor ligands, we showed that I ACh was exclusively mediated by nicotinic acetylcholine receptors. Distinct concentration–response relations of I ACh1 and I ACh2 for these ligands indicated that they are mediated by different types of nicotinic acetylcholine receptors." @default.
• W1971021330 created "2016-06-24" @default.
• W1971021330 creator A5001013872 @default.
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• W1971021330 creator A5050318328 @default.
• W1971021330 creator A5087613872 @default.
• W1971021330 date "2010-05-01" @default.
• W1971021330 modified "2023-09-24" @default.
• W1971021330 title "Cholinergic Currents in Leg Motoneurons of<i>Carausius morosus</i>" @default.
• W1971021330 cites W1525354826 @default.
• W1971021330 cites W1599277155 @default.
• W1971021330 cites W1647659114 @default.
• W1971021330 cites W166199692 @default.
• W1971021330 cites W1669322589 @default.
• W1971021330 cites W1745534060 @default.
• W1971021330 cites W1829316027 @default.
• W1971021330 cites W1906735024 @default.
• W1971021330 cites W1919066930 @default.
• W1971021330 cites W1923575436 @default.
• W1971021330 cites W1927891220 @default.
• W1971021330 cites W1943715850 @default.
• W1971021330 cites W1964665352 @default.
• W1971021330 cites W1965954953 @default.
• W1971021330 cites W1968635324 @default.
• W1971021330 cites W1974018894 @default.
• W1971021330 cites W1974228985 @default.
• W1971021330 cites W1983384221 @default.
• W1971021330 cites W1985378803 @default.
• W1971021330 cites W1987997044 @default.
• W1971021330 cites W1988582613 @default.
• W1971021330 cites W1991436086 @default.
• W1971021330 cites W1994523030 @default.
• W1971021330 cites W1994651643 @default.
• W1971021330 cites W1996303706 @default.
• W1971021330 cites W1997224869 @default.
• W1971021330 cites W1997633311 @default.
• W1971021330 cites W1998716069 @default.
• W1971021330 cites W2005905831 @default.
• W1971021330 cites W2007560803 @default.
• W1971021330 cites W2007814275 @default.
• W1971021330 cites W2009667219 @default.
• W1971021330 cites W2010127347 @default.
• W1971021330 cites W2016249491 @default.
• W1971021330 cites W2016761469 @default.
• W1971021330 cites W2016788043 @default.
• W1971021330 cites W2019556162 @default.
• W1971021330 cites W2021814361 @default.
• W1971021330 cites W2022957145 @default.
• W1971021330 cites W2025611872 @default.
• W1971021330 cites W2026117899 @default.
• W1971021330 cites W2029914481 @default.
• W1971021330 cites W2030966306 @default.
• W1971021330 cites W2034628972 @default.
• W1971021330 cites W2035868015 @default.
• W1971021330 cites W2036028191 @default.
• W1971021330 cites W2036216077 @default.
• W1971021330 cites W2036919968 @default.
• W1971021330 cites W2039083330 @default.
• W1971021330 cites W2040148740 @default.
• W1971021330 cites W2041399253 @default.
• W1971021330 cites W2042224433 @default.
• W1971021330 cites W2043893587 @default.
• W1971021330 cites W2045767621 @default.
• W1971021330 cites W2046797657 @default.
• W1971021330 cites W2047914670 @default.
• W1971021330 cites W2050432697 @default.
• W1971021330 cites W2053696585 @default.
• W1971021330 cites W2056050579 @default.
• W1971021330 cites W2059234084 @default.
• W1971021330 cites W2062206844 @default.
• W1971021330 cites W2063406449 @default.
• W1971021330 cites W2065773356 @default.
• W1971021330 cites W2068778243 @default.
• W1971021330 cites W2071357317 @default.
• W1971021330 cites W2071391526 @default.
• W1971021330 cites W2076639564 @default.
• W1971021330 cites W2077675535 @default.
• W1971021330 cites W2078034710 @default.
• W1971021330 cites W2079440796 @default.
• W1971021330 cites W2081609769 @default.
• W1971021330 cites W2085458221 @default.
• W1971021330 cites W2087400378 @default.
• W1971021330 cites W2092350392 @default.
• W1971021330 cites W2092610981 @default.
• W1971021330 cites W2099542365 @default.
• W1971021330 cites W2100251132 @default.
• W1971021330 cites W2101488656 @default.
• W1971021330 cites W2106819290 @default.
• W1971021330 cites W2110294324 @default.
• W1971021330 cites W2117538765 @default.
• W1971021330 cites W2117768550 @default.
• W1971021330 cites W2117897510 @default.
• W1971021330 cites W2120804871 @default.
• W1971021330 cites W2123847061 @default.
• W1971021330 cites W2128442744 @default.
• W1971021330 cites W2129706672 @default.

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