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• W1971025276 abstract "We investigated the combined effect of increased brain topical K + concentration and reduction of the nitric oxide(NO . ) level caused by nitric oxide scavenging or nitric oxide synthase (NOS) inhibition on regional cerebral blood flow and subarachnoid direct current (DC) potential. Using thiopental-anesthetized male Wistar rats with a closed cranial window preparation, brain topical superfusion of a combination of the NO . scavenger hemoglobin(Hb; 2 mmol/L) and increased K + concentration in the artificial cerebrospinal fluid ([K + ] ACSF ) at 35 mmol/L led to sudden spontaneous transient ischemic events with a decrease of CBF to 14 ± 7% (n = 4) compared with the baseline (100%). The ischemic events lasted for 53 ± 17 minutes and were associated with a negative subarachnoid DC shift of −7.3 ± 0.6 mV of 49 ± 12 minutes' duration. The combination of the NOS inhibitor N-nitro-L-arginine(L-NA, 1 mmol/L) with [K + ] ACSF at 35 mmol/L caused similar spontaneous transient ischemic events in 13 rats. When cortical spreading depression was induced by KCl at a 5-mm distance, a typical cortical spreading hyperemia (CSH) and negative DC shift were measured at the closed cranial window during brain topical superfusion with either physiologic artificial CSF (n = 5), or artificial CSF containing increased [K + ] ACSF at 20 mmol/L (n = 4), [K + ] ACSF at 3 mmol/L combined with L-NA (n = 10), [K + ] ACSF at 10 mmol/L combined with L-NA (five of six animals) or [K + ] ACSF at 3 mmol/L combined with Hb (three of four animals). Cortical spreading depression induced long-lasting transient ischemia instead of CSH, when brain was superfused with either[K + ] ACSF at 20 mmol/L combined with Hb (CBF decrease to 20± 20% duration 25 ± 21 minutes, n = 4), or [K + ] ACSF at 20 mmol/L combined with L-NA (n = 19). Transient ischemia induced by NOS inhibition and [K + ] ACSF at 20 mmol/L propagated at a speed of 3.4 ± 0.6 mm/min, indicating cortical spreading ischemia (CSI). Although CSH did not change oxygen free radical production, as measured on-line by in vivo lucigenin-enhanced chemiluminescence, CSI resulted in the typical radical production pattern of ischemia and reperfusion suggestive of brain damage (n = 4). Nimodipine (2 μg/kg body weight/min intravenously) transformed CSI back to CSH (n = 4). Vehicle had no effect on CSI(n = 4). Our data suggest that the combination of decreased NO . levels and increased subarachnoid K + levels induces spreading depression with acute ischemic CBF response. Thus, a disturbed coupling of metabolism and CBF can cause ischemia. We speculate that CSI may be related to delayed ischemic deficits after subarachnoid hemorrhage, a clinical condition in which the release of Hb and K + from erythrocytes creates a microenvironment similar to the one investigated here." @default.
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• W1971025276 date "1998-09-01" @default.
• W1971025276 modified "2023-10-12" @default.
• W1971025276 title "Nitric Oxide Scavenging by Hemoglobin or Nitric Oxide Synthase Inhibition by <i>N</i>-Nitro-L-Arginine Induces Cortical Spreading Ischemia When K⁺ Is Increased in the Subarachnoid Space" @default.
• W1971025276 cites W1574261673 @default.
• W1971025276 cites W1828807460 @default.
• W1971025276 cites W1841463848 @default.
• W1971025276 cites W1963787523 @default.
• W1971025276 cites W1964120668 @default.
• W1971025276 cites W1972794886 @default.
• W1971025276 cites W1985681964 @default.
• W1971025276 cites W1987355656 @default.
• W1971025276 cites W1990421592 @default.
• W1971025276 cites W1995866170 @default.
• W1971025276 cites W1996314952 @default.
• W1971025276 cites W1996553535 @default.
• W1971025276 cites W1997521952 @default.
• W1971025276 cites W2003868172 @default.
• W1971025276 cites W2004831704 @default.
• W1971025276 cites W2005993198 @default.
• W1971025276 cites W2008784714 @default.
• W1971025276 cites W2010328533 @default.
• W1971025276 cites W2013978911 @default.
• W1971025276 cites W2020092684 @default.
• W1971025276 cites W2021832176 @default.
• W1971025276 cites W2033240573 @default.
• W1971025276 cites W2034693740 @default.
• W1971025276 cites W2035289565 @default.
• W1971025276 cites W2036679359 @default.
• W1971025276 cites W2039261191 @default.
• W1971025276 cites W2041176993 @default.
• W1971025276 cites W2041184529 @default.
• W1971025276 cites W2044512497 @default.
• W1971025276 cites W2046938559 @default.
• W1971025276 cites W2048879756 @default.
• W1971025276 cites W2052678539 @default.
• W1971025276 cites W2060369591 @default.
• W1971025276 cites W2060752639 @default.
• W1971025276 cites W2065843356 @default.
• W1971025276 cites W2067494203 @default.
• W1971025276 cites W2067753627 @default.
• W1971025276 cites W2068005545 @default.
• W1971025276 cites W2072168198 @default.
• W1971025276 cites W2078433387 @default.
• W1971025276 cites W2079405518 @default.
• W1971025276 cites W2083196139 @default.
• W1971025276 cites W2087182196 @default.
• W1971025276 cites W2088629791 @default.
• W1971025276 cites W2095115132 @default.
• W1971025276 cites W2097719568 @default.
• W1971025276 cites W2123744498 @default.
• W1971025276 cites W2141921160 @default.
• W1971025276 cites W2317146405 @default.
• W1971025276 cites W2403877358 @default.
• W1971025276 cites W2469684141 @default.
• W1971025276 cites W2486658413 @default.
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• W1971025276 doi "https://doi.org/10.1097/00004647-199809000-00007" @default.
• W1971025276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9740101" @default.
• W1971025276 hasPublicationYear "1998" @default.
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