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- W1971033148 abstract "The major aim of this study was to determine whether the angiotensin converting enzyme (ACE) inhibitors, captopril or enalapril, restore the diminished vasodilator potency of the endothelium-dependent agonist, acetylcholine (ACh), and the endothelium-derived relaxing factor (EDRF), L-S-nitrosocysteine (L-SNC), in conscious Spontaneously Hypertensive (SH) rats.The hemodynamic responses elicited by i.v. injections of ACh, L-SNC, and nitric oxide donors such as MAHMA NONOate, were determined in SH rats treated for 7 days with captopril, enalapril, or the direct vasodilator hydralazine. The effects of captopril, enalapril or hydralazine on oxidant stress levels in blood serum and aorta of WKY and SH rats were also determined.Captopril, enalapril and hydralazine elicited equivalent falls in mean arterial pressure and systemic vascular resistances in SH rats. ACh- and L-SNC-induced vasodilation were increased in captopril- or enalapril-treated SH rats such that the responses were equal to those in normotensive Wistar Kyoto rats. The attenuated responses of ACh and L-SNC in SH rats were not improved by hydralazine. The vasodilator effects of MAHMA NONOate, which were substantially augmented in SH rats, were not affected by captopril, enalapril or hydralazine. The levels of oxidant stress were markedly reduced in captopril- or enalapril-treated but not hydralazine-treated SH rats.The finding that the ACE inhibitors improved the vasodilator potencies of L-SNC and the EDRF released by ACh in SH rats, suggests that the diminished vasodilator potency of these compounds was due to augmented ACE activity, which increased oxidant stress levels. This study provides the first evidence to support the concept that ACE inhibition lowers arterial pressure in SH rats, at least in part, by restoring the vasodilator potency of endothelium-derived L-SNC." @default.
- W1971033148 created "2016-06-24" @default.
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- W1971033148 date "2006-06-01" @default.
- W1971033148 modified "2023-09-23" @default.
- W1971033148 title "ACE inhibition restores the vasodilator potency of the endothelium-derived relaxing factor, l-S-nitrosocysteine, in conscious Spontaneously Hypertensive rats" @default.
- W1971033148 cites W1482038130 @default.
- W1971033148 cites W1513150735 @default.
- W1971033148 cites W1965980436 @default.
- W1971033148 cites W1966176315 @default.
- W1971033148 cites W1970729803 @default.
- W1971033148 cites W1974300227 @default.
- W1971033148 cites W1977257762 @default.
- W1971033148 cites W1978929986 @default.
- W1971033148 cites W1979321136 @default.
- W1971033148 cites W1984464425 @default.
- W1971033148 cites W1990217750 @default.
- W1971033148 cites W1990382540 @default.
- W1971033148 cites W1993122272 @default.
- W1971033148 cites W1995378957 @default.
- W1971033148 cites W1997572788 @default.
- W1971033148 cites W1998100693 @default.
- W1971033148 cites W1999981918 @default.
- W1971033148 cites W2007328856 @default.
- W1971033148 cites W2009592512 @default.
- W1971033148 cites W2009882535 @default.
- W1971033148 cites W2015996726 @default.
- W1971033148 cites W2017794827 @default.
- W1971033148 cites W2019814232 @default.
- W1971033148 cites W2022595505 @default.
- W1971033148 cites W2022699060 @default.
- W1971033148 cites W2023039109 @default.
- W1971033148 cites W2025530741 @default.
- W1971033148 cites W2028303181 @default.
- W1971033148 cites W2030640146 @default.
- W1971033148 cites W203077421 @default.
- W1971033148 cites W2030974007 @default.
- W1971033148 cites W2036993333 @default.
- W1971033148 cites W2037596330 @default.
- W1971033148 cites W2039368093 @default.
- W1971033148 cites W2042338083 @default.
- W1971033148 cites W2043475869 @default.
- W1971033148 cites W2055875581 @default.
- W1971033148 cites W2062384458 @default.
- W1971033148 cites W2063503589 @default.
- W1971033148 cites W2066957125 @default.
- W1971033148 cites W2067365661 @default.
- W1971033148 cites W2067385238 @default.
- W1971033148 cites W2075228082 @default.
- W1971033148 cites W2077607583 @default.
- W1971033148 cites W2081817866 @default.
- W1971033148 cites W2082364454 @default.
- W1971033148 cites W2082396900 @default.
- W1971033148 cites W2086667396 @default.
- W1971033148 cites W2088561267 @default.
- W1971033148 cites W2092643965 @default.
- W1971033148 cites W2095014707 @default.
- W1971033148 cites W2095368090 @default.
- W1971033148 cites W2097247381 @default.
- W1971033148 cites W2099273954 @default.
- W1971033148 cites W2101289177 @default.
- W1971033148 cites W2101593001 @default.
- W1971033148 cites W2106649791 @default.
- W1971033148 cites W2106877893 @default.
- W1971033148 cites W2110827050 @default.
- W1971033148 cites W2113220448 @default.
- W1971033148 cites W2118519973 @default.
- W1971033148 cites W2127203967 @default.
- W1971033148 cites W2131410124 @default.
- W1971033148 cites W2134260386 @default.
- W1971033148 cites W2137926824 @default.
- W1971033148 cites W2145357314 @default.
- W1971033148 cites W2146301720 @default.
- W1971033148 cites W2149872984 @default.
- W1971033148 cites W2155043219 @default.
- W1971033148 cites W2164910167 @default.
- W1971033148 cites W2170357034 @default.
- W1971033148 cites W2268964358 @default.
- W1971033148 cites W4248818761 @default.
- W1971033148 cites W4293247451 @default.
- W1971033148 doi "https://doi.org/10.1016/j.vph.2006.03.003" @default.
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