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- W1971036381 abstract "Optimal use of recombinant factor VIIa in the control of bleeding episodes in hemophilic patients John PuetzSaint Louis University, Department of Pediatrics, St Louis, Missouri, USAAbstract: One of the last remaining clinical hurdles in the treatment of people with hemophilia is the development of inhibitors. Alloantibodies or autoantibodies directed at coagulation factors render the infusion of coagulation factor concentrates ineffective, and alternative means must be used to achieve hemostasis. Recombinant factor VIIa (rFVIIa) was developed to control bleeding episodes in hemophilic patients with inhibitors. Clinical efficacy in achieving hemostasis in inhibitor patients was demonstrated by a compassionate-use protocol, as well as in randomized controlled trials. To date, over 1.5 million doses of rFVIIa have been given to inhibitor patients, with an excellent efficacy and safety record. Because of its short half-life, alternative means of dosing and infusing rFVIIa have been explored and are reviewed here.Keywords: hemophilia, inhibitor, recombinant, factor VIIa, inhibitors" @default.
- W1971036381 created "2016-06-24" @default.
- W1971036381 creator A5045666069 @default.
- W1971036381 date "2010-06-01" @default.
- W1971036381 modified "2023-09-26" @default.
- W1971036381 title "Optimal use of recombinant factor VIIa in the control of bleeding episodes in hemophilic patients" @default.
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- W1971036381 doi "https://doi.org/10.2147/dddt.s6628" @default.
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