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• W1971036555 abstract "The contribution of pathology to toxicity assessment is invaluable but often not clearly understood. Pathology endpoints are the central response around which human health risk assessment is frequently determined; therefore, it is important that the general toxicology community understand current concepts and nomenclature of toxicologic pathology. Toxicologic pathology encompasses the study of changes in tissue morphology that help define the risk of exposure to xenobiotics. Toxicologic pathology is a discipline that has changed and adapted over time including methods of analysis and nomenclature of lesions. As risk assessments are updated for chemicals in commerce, frequently the older literature must be reviewed and reevaluated. When interpreting pathology data from animal studies, it is important to consider the biological significance of a lesion as well as its relationship to the ultimate adverse health effect. Assessing the potential for a chemical to cause harm to humans must include the examination of the entire pathology database in context of the study design, the mode of action of the chemical of concern, and using the most current interpretation of a lesion to determine the significance for human health effects of a particular tissue response." @default.
• W1971036555 created "2016-06-24" @default.
• W1971036555 creator A5015482244 @default.
• W1971036555 creator A5034576675 @default.
• W1971036555 date "2005-02-01" @default.
• W1971036555 modified "2023-09-23" @default.
• W1971036555 title "Confounders in interpreting pathology for safety and risk assessment" @default.
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• W1971036555 doi "https://doi.org/10.1016/j.taap.2004.06.022" @default.
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