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- W1971036626 abstract "(2000) BMJ 320, 350. Damoiseaux RA, van Balen FA, Hoes AW, et al. . Primary care based randomised, double blind trial of amoxicillin versus placebo for acute otitis media in children aged under 2 years. . Feb 5; . : . –4 . [OpenUrl][1][Abstract/FREE Full Text][2] QUESTION: In children with acute otitis media (AOM) who are 6–24 months of age, how effective is amoxicillin in improving signs and symptoms? Randomised (allocation concealed*), blinded (clinicians and parents),* placebo controlled trial with 6 week follow up. 53 general practices in the Netherlands. 240 children who were between 6 and 24 months of age (mean age 13 mo, 54% boys) and had AOM and ≥1 symptom of acute infection (fever, recent earache, general malaise, or recent irritability). Exclusion criteria were antibiotic therapy in the past 4 weeks, allergy to amoxicillin, compromised immunity, craniofacial abnormalities, or Down's syndrome. Follow up was 91% at 11 days and 88% at 6 weeks. Patients were allocated to amoxicillin suspension, 40 mg/kg of body weight per day (n=117), or placebo (n=123) for 10 days. … [1]: {openurl}?query=rft.jtitle%253DBMJ%26rft.stitle%253DBMJ%26rft.issn%253D0007-1447%26rft.aulast%253DDamoiseaux%26rft.auinit1%253DR.%2BA%2BM%2BJ%26rft.volume%253D320%26rft.issue%253D7231%26rft.spage%253D350%26rft.epage%253D354%26rft.atitle%253DPrimary%2Bcare%2Bbased%2Brandomised%252C%2Bdouble%2Bblind%2Btrial%2Bof%2Bamoxicillin%2Bversus%2Bplacebo%2Bfor%2Bacute%2Botitis%2Bmedia%2Bin%2Bchildren%2Baged%2Bunder%2B2%2Byears%26rft_id%253Dinfo%253Adoi%252F10.1136%252Fbmj.320.7231.350%26rft_id%253Dinfo%253Apmid%252F10657332%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=bmj&resid=320/7231/350&atom=%2Febmed%2F5%2F5%2F149.atom" @default.
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- W1971036626 date "2000-09-01" @default.
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- W1971036626 title "Amoxicillin resolved otitis media symptoms in young children better than did placebo at day 4 but not at day 11" @default.
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