FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971051736> ?p ?o ?g. }

• W1971051736 endingPage "277" @default.
• W1971051736 startingPage "267" @default.
• W1971051736 abstract "In adult animals, airway fluid secretion is enhanced reflexly via central nervous system pathways, and locally mediators such as substance P. To evaluat the role of maturation on these regulatory mechanisms, we compared the effects of reflex stimulation and intravenous substance P administration on airway secretionin anaesthetized, paralyzed and artificially ventilated piglets, 9 to 22 days of age, and older piglets all aged 10 weeks. Airway secretion was monitored by counting the hillocks appearing in the upper trachea in an exposed field of tracheal epithelium (1.2 cm2) coated with powdered tantalum. In younger animals, mechanical stimulation of the larynx had no discernible effect on tracheal submucosal gland secretion. Neither excitation of airway irritant receptors nor stimulation of pulmonary C-fiber receptors by capsaicin caused a significant increase of fluid secretion from tracheal submucosal glands. In addition, stimulation of peripheral chemoreceptors by ventilating animals 12% O2 in N2, and 6% O2 in N2, failed to induce a substantial change in airway secretion, when compared with number of hillocks in the control period. Furthermore, administration of sodium cyanide had little or no effect on baseline secretion. In contrast, to the weak reflex responses in younger piglets electrical stimulation of the vagus nerve caused the number of hillocks to increase on average by 16.3 ± 2.3 (P < 0.01). In addition, local application of a pledget soaked in solution of methacholine caused the number of hillocks to increase by 32.1 ± 5.2 (P < 0.01). Intravenous administration of substance P also induced an augmentation in fluid secretion. Increase in concentration of substance P (10−8, 10−7, 10−6, and 10−5 M, 1 ml) was associated with a concomitant elevation in the number of activated submucosal glands 5.3 ± 2.6, 10.0 ± 4.4, 27.1 ± 4.5, 41 ± 5). In older piglets, stimulation of laryngeal mucosa, airway irritant receptors, as well as stimulation of pulmonary C-fiber receptors induced a significant increase in tracheal secretion, although stimulation of peripheral chemoreceptors had no effect on airway secretion. These data suggest that reflex responses of submucosal glands are weak during early postnatal development, however, tracheal submucosal glands do respond to exogenously administered cholinergic substances and tachykinin peptides." @default.
• W1971051736 created "2016-06-24" @default.
• W1971051736 creator A5019717439 @default.
• W1971051736 creator A5029701823 @default.
• W1971051736 creator A5032318856 @default.
• W1971051736 creator A5033749081 @default.
• W1971051736 creator A5055743128 @default.
• W1971051736 date "1990-12-01" @default.
• W1971051736 modified "2023-09-27" @default.
• W1971051736 title "Reflex and chemical responses of tracheal submucosal glands in piglets" @default.
• W1971051736 cites W1812295033 @default.
• W1971051736 cites W1827908121 @default.
• W1971051736 cites W1970936501 @default.
• W1971051736 cites W1979074666 @default.
• W1971051736 cites W1986783654 @default.
• W1971051736 cites W1995408834 @default.
• W1971051736 cites W2016431526 @default.
• W1971051736 cites W2050894508 @default.
• W1971051736 cites W2070367703 @default.
• W1971051736 cites W2080335457 @default.
• W1971051736 cites W2179280598 @default.
• W1971051736 cites W2281642326 @default.
• W1971051736 cites W2296139167 @default.
• W1971051736 cites W2297518875 @default.
• W1971051736 cites W2323913100 @default.
• W1971051736 cites W2413841446 @default.
• W1971051736 doi "https://doi.org/10.1016/0034-5687(90)90097-i" @default.
• W1971051736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1706884" @default.
• W1971051736 hasPublicationYear "1990" @default.
• W1971051736 type Work @default.
• W1971051736 sameAs 1971051736 @default.
• W1971051736 citedByCount "27" @default.
• W1971051736 countsByYear W19710517362013 @default.
• W1971051736 countsByYear W19710517362014 @default.
• W1971051736 countsByYear W19710517362015 @default.
• W1971051736 countsByYear W19710517362017 @default.
• W1971051736 countsByYear W19710517362023 @default.
• W1971051736 crossrefType "journal-article" @default.
• W1971051736 hasAuthorship W1971051736A5019717439 @default.
• W1971051736 hasAuthorship W1971051736A5029701823 @default.
• W1971051736 hasAuthorship W1971051736A5032318856 @default.
• W1971051736 hasAuthorship W1971051736A5033749081 @default.
• W1971051736 hasAuthorship W1971051736A5055743128 @default.
• W1971051736 hasConcept C126322002 @default.
• W1971051736 hasConcept C134018914 @default.
• W1971051736 hasConcept C170493617 @default.
• W1971051736 hasConcept C24998067 @default.
• W1971051736 hasConcept C2776385078 @default.
• W1971051736 hasConcept C2780051329 @default.
• W1971051736 hasConcept C42219234 @default.
• W1971051736 hasConcept C49039625 @default.
• W1971051736 hasConcept C71924100 @default.
• W1971051736 hasConcept C83974742 @default.
• W1971051736 hasConceptScore W1971051736C126322002 @default.
• W1971051736 hasConceptScore W1971051736C134018914 @default.
• W1971051736 hasConceptScore W1971051736C170493617 @default.
• W1971051736 hasConceptScore W1971051736C24998067 @default.
• W1971051736 hasConceptScore W1971051736C2776385078 @default.
• W1971051736 hasConceptScore W1971051736C2780051329 @default.
• W1971051736 hasConceptScore W1971051736C42219234 @default.
• W1971051736 hasConceptScore W1971051736C49039625 @default.
• W1971051736 hasConceptScore W1971051736C71924100 @default.
• W1971051736 hasConceptScore W1971051736C83974742 @default.
• W1971051736 hasIssue "3" @default.
• W1971051736 hasLocation W19710517361 @default.
• W1971051736 hasLocation W19710517362 @default.
• W1971051736 hasOpenAccess W1971051736 @default.
• W1971051736 hasPrimaryLocation W19710517361 @default.
• W1971051736 hasRelatedWork W1984619393 @default.
• W1971051736 hasRelatedWork W2020884724 @default.
• W1971051736 hasRelatedWork W2034768996 @default.
• W1971051736 hasRelatedWork W2054992011 @default.
• W1971051736 hasRelatedWork W2060618991 @default.
• W1971051736 hasRelatedWork W2064416809 @default.
• W1971051736 hasRelatedWork W2130243588 @default.
• W1971051736 hasRelatedWork W2161296685 @default.
• W1971051736 hasRelatedWork W2163700154 @default.
• W1971051736 hasRelatedWork W1996741910 @default.
• W1971051736 hasVolume "82" @default.
• W1971051736 isParatext "false" @default.
• W1971051736 isRetracted "false" @default.
• W1971051736 magId "1971051736" @default.
• W1971051736 workType "article" @default.