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- W1971056543 abstract "Abstract The dissolution rate of a standard tablet containing acetylsalicylic acid was measured with a continuous flow cell method. The same tablet was given to 14 subjects and salicylate saliva levels were monitored. Using the Wagner-Nelson method, the absorption kinetics were determined to follow a first-order process. The absorption rate constant was calculated and compared with the dissolution rate constant of the in vitro experiment. Under the same conditions 3 other tablets containing acetylsalicylic acid were investigated. From the obtained dissolution data the salicylate saliva levels were predicted and compared with the measured concentrations. Their good agreement indicated the ability of continuous flow systems to give valid information for quality control and tablet formulation screening." @default.
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- W1971056543 date "1983-06-01" @default.
- W1971056543 modified "2023-09-27" @default.
- W1971056543 title "In vivo-in vitro correlations of salicylate saliva levels and continuous flow cell dissolution rates" @default.
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- W1971056543 doi "https://doi.org/10.1016/0378-5173(83)90140-0" @default.
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