FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971060618> ?p ?o ?g. }

• W1971060618 endingPage "626" @default.
• W1971060618 startingPage "617" @default.
• W1971060618 abstract "Macrophages undergo fusion to form multinucleated giant cells in several pathologic conditions, including the foreign body response (FBR). We detected high levels of matrix metalloproteinase (MMP)-9 during macrophage fusion in vitro and in foreign body giant cells (FBGCs) in vivo. Wild-type (WT) bone marrow-derived macrophages were induced to fuse with IL-4 in the presence of MMP-9 function-blocking antibodies and displayed reduced fusion. A similar defect, characterized by delayed shape change and abnormal morphology, was observed in MMP-9 null macrophages. Analysis of the FBR in MMP-9 null mice was then pursued to evaluate the significance of these findings. Specifically, mixed cellulose ester disks and polyvinyl alcohol sponges were implanted s.c. in MMP-9 null and WT mice and excised 2-4 weeks later. Histochemical and immunohistochemical analyses indicated equal macrophage recruitment between MMP-9 null and WT mice, but FBGC formation was compromised in the former. In addition, MMP-9 null mice displayed abnormalities in extracellular matrix assembly and angiogenesis. Consistent with a requirement for MMP-9 in fusion, we also observed reduced MMP-9 levels in MCP-1 null macrophages, previously shown to be defective in FBGC formation. Collectively, our studies show abnormalities in MMP-9 null mice during the FBR and suggest a role for MMP-9 in macrophage fusion." @default.
• W1971060618 created "2016-06-24" @default.
• W1971060618 creator A5018589969 @default.
• W1971060618 creator A5019694310 @default.
• W1971060618 creator A5029924084 @default.
• W1971060618 creator A5043009176 @default.
• W1971060618 creator A5043237777 @default.
• W1971060618 creator A5056611075 @default.
• W1971060618 creator A5074263750 @default.
• W1971060618 creator A5078057155 @default.
• W1971060618 creator A5083900496 @default.
• W1971060618 date "2009-01-13" @default.
• W1971060618 modified "2023-10-15" @default.
• W1971060618 title "Macrophage fusion, giant cell formation, and the foreign body response require matrix metalloproteinase 9" @default.
• W1971060618 cites W1574172480 @default.
• W1971060618 cites W1581404300 @default.
• W1971060618 cites W1730313527 @default.
• W1971060618 cites W1975278509 @default.
• W1971060618 cites W1980755477 @default.
• W1971060618 cites W1986130046 @default.
• W1971060618 cites W1987641892 @default.
• W1971060618 cites W1987825791 @default.
• W1971060618 cites W1995063875 @default.
• W1971060618 cites W1995185323 @default.
• W1971060618 cites W1996983058 @default.
• W1971060618 cites W1998308009 @default.
• W1971060618 cites W2009021998 @default.
• W1971060618 cites W2012413811 @default.
• W1971060618 cites W2013411867 @default.
• W1971060618 cites W2013797466 @default.
• W1971060618 cites W2016411107 @default.
• W1971060618 cites W2019584310 @default.
• W1971060618 cites W2019641554 @default.
• W1971060618 cites W2022071421 @default.
• W1971060618 cites W2022718682 @default.
• W1971060618 cites W2024687717 @default.
• W1971060618 cites W2028111423 @default.
• W1971060618 cites W2029264336 @default.
• W1971060618 cites W2030695078 @default.
• W1971060618 cites W2030776545 @default.
• W1971060618 cites W2032478134 @default.
• W1971060618 cites W2036834425 @default.
• W1971060618 cites W2038060277 @default.
• W1971060618 cites W2051651031 @default.
• W1971060618 cites W2053642612 @default.
• W1971060618 cites W2058581224 @default.
• W1971060618 cites W2059657578 @default.
• W1971060618 cites W2060074114 @default.
• W1971060618 cites W2071366784 @default.
• W1971060618 cites W2079236567 @default.
• W1971060618 cites W2086597792 @default.
• W1971060618 cites W2093979559 @default.
• W1971060618 cites W2099499481 @default.
• W1971060618 cites W2109934888 @default.
• W1971060618 cites W2110310870 @default.
• W1971060618 cites W2111239144 @default.
• W1971060618 cites W2119457381 @default.
• W1971060618 cites W2134379576 @default.
• W1971060618 cites W2144688518 @default.
• W1971060618 cites W2149049320 @default.
• W1971060618 cites W2154401382 @default.
• W1971060618 cites W2156961478 @default.
• W1971060618 cites W2159232436 @default.
• W1971060618 cites W2163147093 @default.
• W1971060618 cites W2168854100 @default.
• W1971060618 cites W2171267420 @default.
• W1971060618 cites W2172114097 @default.
• W1971060618 doi "https://doi.org/10.1189/jlb.1008588" @default.
• W1971060618 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2656428" @default.
• W1971060618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19141565" @default.
• W1971060618 hasPublicationYear "2009" @default.
• W1971060618 type Work @default.
• W1971060618 sameAs 1971060618 @default.
• W1971060618 citedByCount "126" @default.
• W1971060618 countsByYear W19710606182012 @default.
• W1971060618 countsByYear W19710606182013 @default.
• W1971060618 countsByYear W19710606182014 @default.
• W1971060618 countsByYear W19710606182015 @default.
• W1971060618 countsByYear W19710606182016 @default.
• W1971060618 countsByYear W19710606182017 @default.
• W1971060618 countsByYear W19710606182018 @default.
• W1971060618 countsByYear W19710606182019 @default.
• W1971060618 countsByYear W19710606182020 @default.
• W1971060618 countsByYear W19710606182021 @default.
• W1971060618 countsByYear W19710606182022 @default.
• W1971060618 countsByYear W19710606182023 @default.
• W1971060618 crossrefType "journal-article" @default.
• W1971060618 hasAuthorship W1971060618A5018589969 @default.
• W1971060618 hasAuthorship W1971060618A5019694310 @default.
• W1971060618 hasAuthorship W1971060618A5029924084 @default.
• W1971060618 hasAuthorship W1971060618A5043009176 @default.
• W1971060618 hasAuthorship W1971060618A5043237777 @default.
• W1971060618 hasAuthorship W1971060618A5056611075 @default.
• W1971060618 hasAuthorship W1971060618A5074263750 @default.
• W1971060618 hasAuthorship W1971060618A5078057155 @default.
• W1971060618 hasAuthorship W1971060618A5083900496 @default.
• W1971060618 hasBestOaLocation W19710606182 @default.
• W1971060618 hasConcept C106487976 @default.

• next