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- W1971062113 abstract "Abstract Assessment of 45 Ca 2+ transport in rat brain mitochondria following in vitro and in vivo exposures to the neurotoxic insecticide chlordecone revealed a locus for chlordecone's mitochondrial impairment in the coupling reactions of oxidative phosphorylation. Mitochondrial 45 Ca 2+ transport supported by either 2 m m succinate (free energy supplied via electron transport) or 800 μ m ATP (free energy supplied via the Mg 2+ ATPase reaction) was inhibited by low concentrations of chlordecone (10 −8 –10 −5 m ). Administration of a tremorigenic dose (40 mg/kg, po) of chlordecone to rats similarly inhibited both succinate- and ATP-supported 45 Ca 2+ uptake in brain mitochondria in vitro . Studies on the subcellular distribution of [ 14 C]chlordecone in rat brain following in vivo administrations were compared to those on the mitochondrial uptake of [ 14 C]chlordecone in vitro . Administration of the 40-mg/kg tremorigenic dose of chlordecone produced mitochondrial chlordecone concentrations which were comparable to the tissue concentrations achieved by exposing mitochondria to a 2 × 10 −6 m concentration of chlordecone in vitro . These data lend further support for mitochondrial inhibition as a mechanism for chlordecone toxicity." @default.
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- W1971062113 date "1979-10-01" @default.
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- W1971062113 title "Inhibition of rat brain mitochondrial calcium transport by chlordecone" @default.
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- W1971062113 doi "https://doi.org/10.1016/0041-008x(79)90021-8" @default.
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