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- W1971077072 abstract "Influenza-related mortality is often caused by secondary bacterial pneumonia. We have previously shown that the tryptophan-catabolizing enzyme indoleamine-2,3-dioxygenase (IDO) critically impairs host defense against secondary bacterial pneumonia [1]. Since inhibition of IDO resulted in increased neutrophil numbers during primary viral infection, we hypothesized that tryptophan degradation and/or the generation of downstream metabolites induces neutrophil apoptosis. In the present study we aimed to investigate the impact of IDO-mediated tryptophan metabolism on neutrophil apoptosis in vitro and in vivo." @default.
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- W1971077072 date "2011-02-01" @default.
- W1971077072 modified "2023-10-16" @default.
- W1971077072 title "Indoleamine-2,3-dioxygenase activity induces neutrophil apoptosis" @default.
- W1971077072 cites W2116742245 @default.
- W1971077072 doi "https://doi.org/10.1186/cc9628" @default.
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