Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971082641> ?p ?o ?g. }
- W1971082641 endingPage "124" @default.
- W1971082641 startingPage "115" @default.
- W1971082641 abstract "Mitochondrial number and function are altered in response to external stimuli in eukaryotes. While several transcription/replication factors directly regulate mitochondrial genes, the coordination of these factors into a program responsive to the environment is not understood. We show here that PGC-1, a cold-inducible coactivator of nuclear receptors, stimulates mitochondrial biogenesis and respiration in muscle cells through an induction of uncoupling protein 2 (UCP-2) and through regulation of the nuclear respiratory factors (NRFs). PGC-1 stimulates a powerful induction of NRF-1 and NRF-2 gene expression; in addition, PGC-1 binds to and coactivates the transcriptional function of NRF-1 on the promoter for mitochondrial transcription factor A (mtTFA), a direct regulator of mitochondrial DNA replication/transcription. These data elucidate a pathway that directly links external physiological stimuli to the regulation of mitochondrial biogenesis and function." @default.
- W1971082641 created "2016-06-24" @default.
- W1971082641 creator A5009860591 @default.
- W1971082641 creator A5022918796 @default.
- W1971082641 creator A5024782501 @default.
- W1971082641 creator A5036985869 @default.
- W1971082641 creator A5039208792 @default.
- W1971082641 creator A5068403328 @default.
- W1971082641 creator A5068971521 @default.
- W1971082641 creator A5070153869 @default.
- W1971082641 creator A5080814280 @default.
- W1971082641 creator A5085943861 @default.
- W1971082641 creator A5089703678 @default.
- W1971082641 date "1999-07-01" @default.
- W1971082641 modified "2023-10-16" @default.
- W1971082641 title "Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1" @default.
- W1971082641 cites W1483361087 @default.
- W1971082641 cites W1513078811 @default.
- W1971082641 cites W1535995715 @default.
- W1971082641 cites W1548912336 @default.
- W1971082641 cites W1550000221 @default.
- W1971082641 cites W1792370315 @default.
- W1971082641 cites W193153926 @default.
- W1971082641 cites W1968197570 @default.
- W1971082641 cites W1972836378 @default.
- W1971082641 cites W1974418613 @default.
- W1971082641 cites W1987779112 @default.
- W1971082641 cites W1991049622 @default.
- W1971082641 cites W1999763722 @default.
- W1971082641 cites W2002519246 @default.
- W1971082641 cites W2002662437 @default.
- W1971082641 cites W2008632158 @default.
- W1971082641 cites W2014993721 @default.
- W1971082641 cites W2017860616 @default.
- W1971082641 cites W2021760176 @default.
- W1971082641 cites W2023530279 @default.
- W1971082641 cites W2040371828 @default.
- W1971082641 cites W2042789770 @default.
- W1971082641 cites W2044494908 @default.
- W1971082641 cites W2045639368 @default.
- W1971082641 cites W2050797689 @default.
- W1971082641 cites W2057498089 @default.
- W1971082641 cites W2062073832 @default.
- W1971082641 cites W2063873651 @default.
- W1971082641 cites W2068876485 @default.
- W1971082641 cites W2089471108 @default.
- W1971082641 cites W2092823267 @default.
- W1971082641 cites W2096712675 @default.
- W1971082641 cites W2104421136 @default.
- W1971082641 cites W2131538153 @default.
- W1971082641 cites W2134297608 @default.
- W1971082641 cites W2134920653 @default.
- W1971082641 cites W2138289723 @default.
- W1971082641 cites W2160811167 @default.
- W1971082641 cites W2162932753 @default.
- W1971082641 cites W2173353469 @default.
- W1971082641 cites W2309719929 @default.
- W1971082641 cites W2319231450 @default.
- W1971082641 cites W4454459 @default.
- W1971082641 doi "https://doi.org/10.1016/s0092-8674(00)80611-x" @default.
- W1971082641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10412986" @default.
- W1971082641 hasPublicationYear "1999" @default.
- W1971082641 type Work @default.
- W1971082641 sameAs 1971082641 @default.
- W1971082641 citedByCount "3560" @default.
- W1971082641 countsByYear W19710826412012 @default.
- W1971082641 countsByYear W19710826412013 @default.
- W1971082641 countsByYear W19710826412014 @default.
- W1971082641 countsByYear W19710826412015 @default.
- W1971082641 countsByYear W19710826412016 @default.
- W1971082641 countsByYear W19710826412017 @default.
- W1971082641 countsByYear W19710826412018 @default.
- W1971082641 countsByYear W19710826412019 @default.
- W1971082641 countsByYear W19710826412020 @default.
- W1971082641 countsByYear W19710826412021 @default.
- W1971082641 countsByYear W19710826412022 @default.
- W1971082641 countsByYear W19710826412023 @default.
- W1971082641 crossrefType "journal-article" @default.
- W1971082641 hasAuthorship W1971082641A5009860591 @default.
- W1971082641 hasAuthorship W1971082641A5022918796 @default.
- W1971082641 hasAuthorship W1971082641A5024782501 @default.
- W1971082641 hasAuthorship W1971082641A5036985869 @default.
- W1971082641 hasAuthorship W1971082641A5039208792 @default.
- W1971082641 hasAuthorship W1971082641A5068403328 @default.
- W1971082641 hasAuthorship W1971082641A5068971521 @default.
- W1971082641 hasAuthorship W1971082641A5070153869 @default.
- W1971082641 hasAuthorship W1971082641A5080814280 @default.
- W1971082641 hasAuthorship W1971082641A5085943861 @default.
- W1971082641 hasAuthorship W1971082641A5089703678 @default.
- W1971082641 hasBestOaLocation W19710826411 @default.
- W1971082641 hasConcept C104317684 @default.
- W1971082641 hasConcept C12304452 @default.
- W1971082641 hasConcept C131934819 @default.
- W1971082641 hasConcept C138885662 @default.
- W1971082641 hasConcept C155432671 @default.
- W1971082641 hasConcept C169415338 @default.
- W1971082641 hasConcept C179926584 @default.
- W1971082641 hasConcept C24586158 @default.