Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971090593> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1971090593 endingPage "14965" @default.
- W1971090593 startingPage "14960" @default.
- W1971090593 abstract "Twenty-four base pairs of the human antioxidant response element (hARE) are required for high basal transcription of the NAD(P)H:quinone oxidoreductase 1 (NQO 1 ) gene and its induction in response to xenobiotics and antioxidants. hARE is a unique cis-element that contains one perfect and one imperfect AP1 element arranged as inverse repeats separated by 3 bp, followed by a “GC” box. We report here that Jun, Fos, Fra, and Nrf nuclear transcription factors bind to the hARE. Overexpression of cDNA derived combinations of the nuclear proteins Jun and Fos or Jun and Fra1 repressed hARE-mediated chloramphenicol acetyltransferase (CAT) gene expression in transfected human hepatoblastoma (Hep-G2) cells. Further experiments suggested that this repression was due to overexpression of c-Fos and Fra1, but not due to Jun proteins. The Jun (c-Jun, Jun-B, and Jun-D) proteins in all the possible combinations were more or less ineffective in repression or upregulation of hARE-mediated gene expression. Interestingly, overexpression of Nrf1 and Nrf2 individually in Hep-G2 and monkey kidney (COS1) cells significantly increased CAT gene expression from reporter plasmid hARE-thymidine kinase-CAT in transfected cells that were inducible by β-naphthoflavone and tert -butyl hydroquinone. These results indicated that hARE-mediated expression of the NQO 1 gene and its induction by xenobiotics and antioxidants are mediated by Nrf1 and Nrf2. The hARE-mediated basal expression, however, is repressed by overexpression of c-Fos and Fra1." @default.
- W1971090593 created "2016-06-24" @default.
- W1971090593 creator A5005883777 @default.
- W1971090593 creator A5027903995 @default.
- W1971090593 date "1996-12-10" @default.
- W1971090593 modified "2023-10-16" @default.
- W1971090593 title "Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase <sub>1</sub> gene" @default.
- W1971090593 cites W1486158855 @default.
- W1971090593 cites W1508786321 @default.
- W1971090593 cites W1603378617 @default.
- W1971090593 cites W1903041271 @default.
- W1971090593 cites W1972441677 @default.
- W1971090593 cites W1974525592 @default.
- W1971090593 cites W1975512386 @default.
- W1971090593 cites W1975987535 @default.
- W1971090593 cites W1987453246 @default.
- W1971090593 cites W1991265255 @default.
- W1971090593 cites W1995894679 @default.
- W1971090593 cites W2004995908 @default.
- W1971090593 cites W2014801103 @default.
- W1971090593 cites W2020178430 @default.
- W1971090593 cites W2051841132 @default.
- W1971090593 cites W2081153112 @default.
- W1971090593 cites W2174669178 @default.
- W1971090593 cites W2410749618 @default.
- W1971090593 doi "https://doi.org/10.1073/pnas.93.25.14960" @default.
- W1971090593 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/26245" @default.
- W1971090593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8962164" @default.
- W1971090593 hasPublicationYear "1996" @default.
- W1971090593 type Work @default.
- W1971090593 sameAs 1971090593 @default.
- W1971090593 citedByCount "993" @default.
- W1971090593 countsByYear W19710905932012 @default.
- W1971090593 countsByYear W19710905932013 @default.
- W1971090593 countsByYear W19710905932014 @default.
- W1971090593 countsByYear W19710905932015 @default.
- W1971090593 countsByYear W19710905932016 @default.
- W1971090593 countsByYear W19710905932017 @default.
- W1971090593 countsByYear W19710905932018 @default.
- W1971090593 countsByYear W19710905932019 @default.
- W1971090593 countsByYear W19710905932020 @default.
- W1971090593 countsByYear W19710905932021 @default.
- W1971090593 countsByYear W19710905932022 @default.
- W1971090593 countsByYear W19710905932023 @default.
- W1971090593 crossrefType "journal-article" @default.
- W1971090593 hasAuthorship W1971090593A5005883777 @default.
- W1971090593 hasAuthorship W1971090593A5027903995 @default.
- W1971090593 hasBestOaLocation W19710905931 @default.
- W1971090593 hasConcept C102280478 @default.
- W1971090593 hasConcept C104317684 @default.
- W1971090593 hasConcept C150194340 @default.
- W1971090593 hasConcept C153911025 @default.
- W1971090593 hasConcept C161733203 @default.
- W1971090593 hasConcept C165864922 @default.
- W1971090593 hasConcept C2780730277 @default.
- W1971090593 hasConcept C54009773 @default.
- W1971090593 hasConcept C55493867 @default.
- W1971090593 hasConcept C86339819 @default.
- W1971090593 hasConcept C86803240 @default.
- W1971090593 hasConceptScore W1971090593C102280478 @default.
- W1971090593 hasConceptScore W1971090593C104317684 @default.
- W1971090593 hasConceptScore W1971090593C150194340 @default.
- W1971090593 hasConceptScore W1971090593C153911025 @default.
- W1971090593 hasConceptScore W1971090593C161733203 @default.
- W1971090593 hasConceptScore W1971090593C165864922 @default.
- W1971090593 hasConceptScore W1971090593C2780730277 @default.
- W1971090593 hasConceptScore W1971090593C54009773 @default.
- W1971090593 hasConceptScore W1971090593C55493867 @default.
- W1971090593 hasConceptScore W1971090593C86339819 @default.
- W1971090593 hasConceptScore W1971090593C86803240 @default.
- W1971090593 hasIssue "25" @default.
- W1971090593 hasLocation W19710905931 @default.
- W1971090593 hasLocation W19710905932 @default.
- W1971090593 hasLocation W19710905933 @default.
- W1971090593 hasLocation W19710905934 @default.
- W1971090593 hasOpenAccess W1971090593 @default.
- W1971090593 hasPrimaryLocation W19710905931 @default.
- W1971090593 hasRelatedWork W1964623084 @default.
- W1971090593 hasRelatedWork W1981892740 @default.
- W1971090593 hasRelatedWork W2025582510 @default.
- W1971090593 hasRelatedWork W2072381892 @default.
- W1971090593 hasRelatedWork W2088859732 @default.
- W1971090593 hasRelatedWork W2091058548 @default.
- W1971090593 hasRelatedWork W2149484944 @default.
- W1971090593 hasRelatedWork W2156042726 @default.
- W1971090593 hasRelatedWork W2161722978 @default.
- W1971090593 hasRelatedWork W2501754528 @default.
- W1971090593 hasVolume "93" @default.
- W1971090593 isParatext "false" @default.
- W1971090593 isRetracted "false" @default.
- W1971090593 magId "1971090593" @default.
- W1971090593 workType "article" @default.