FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971094792> ?p ?o ?g. }

• W1971094792 endingPage "72" @default.
• W1971094792 startingPage "65" @default.
• W1971094792 abstract "Microglia and macrophages express the alpha(M)/beta(2) integrin complement-receptor-3 (CR3/MAC-1; CD11b/CD18) and scavenger-receptor-AI/II (SRAI/II). Both can mediate myelin phagocytosis. We document that CR3/MAC-1 mediated myelin phagocytosis in microglia is modulated by complement and anti-CR3/MAC-1 mAbs. Complement augmented phagocytosis twofold. Anti-alpha(M) mAbs M1/70 and 5C6 inhibited and anti-beta(2) mAb M18/2 augmented myelin phagocytosis in the presence and absence of active complement. Active complement modulated phagocytosis inhibition by M1/70 and 5C6 and phagocytosis augmentation by M18/2. CR3/MAC-1 mediated myelin phagocytosis may thus be, at least partially, independent of but modulated by complement. Anti-beta(2) mAb Game-46 did not affect phagocytosis. However, combining M18/2 with Game-46 resulted in phagocytosis augmentation that was larger in magnitude than that induced by M18/2 alone. Thus, phagocytosis augmentation induced by one anti-beta(2) mAb was potentiated by another anti-beta(2) mAb. Combining M1/70 or 5C6 with M18/2 inhibited M18/2-induced augmentation. Overall, mAbs-induced phagocytosis modulation ranged three- to sevenfold from inhibition to augmentation. Anti-CR3/MAC-1 mAbs may reveal a mechanism by which native extracellular molecules bind to and modulate CR3/MAC-1 mediated myelin phagocytosis in microglia and macrophages. We further document SRAI/II mediated myelin phagocytosis in microglia and CR3/MAC-1 contributing to myelin phagocytosis two- to threefold more than SRAI/II when the two receptors function together." @default.
• W1971094792 created "2016-06-24" @default.
• W1971094792 creator A5041874079 @default.
• W1971094792 creator A5043618169 @default.
• W1971094792 date "2003-02-01" @default.
• W1971094792 modified "2023-09-23" @default.
• W1971094792 title "Complement-receptor-3 and scavenger-receptor-AI/II mediated myelin phagocytosis in microglia and macrophages" @default.
• W1971094792 cites W1487485532 @default.
• W1971094792 cites W1566509581 @default.
• W1971094792 cites W1572472402 @default.
• W1971094792 cites W1613698407 @default.
• W1971094792 cites W1928626614 @default.
• W1971094792 cites W1968547119 @default.
• W1971094792 cites W1970483666 @default.
• W1971094792 cites W1992551731 @default.
• W1971094792 cites W1993711898 @default.
• W1971094792 cites W1994360619 @default.
• W1971094792 cites W2001748009 @default.
• W1971094792 cites W2002377750 @default.
• W1971094792 cites W2008863207 @default.
• W1971094792 cites W2010809868 @default.
• W1971094792 cites W2015831421 @default.
• W1971094792 cites W2016265174 @default.
• W1971094792 cites W2025778924 @default.
• W1971094792 cites W2032304318 @default.
• W1971094792 cites W2033677399 @default.
• W1971094792 cites W2038039322 @default.
• W1971094792 cites W2056398986 @default.
• W1971094792 cites W2060678482 @default.
• W1971094792 cites W2078800769 @default.
• W1971094792 cites W2082906462 @default.
• W1971094792 cites W2085632366 @default.
• W1971094792 cites W2087797124 @default.
• W1971094792 cites W2091455355 @default.
• W1971094792 cites W2092809740 @default.
• W1971094792 cites W2102324547 @default.
• W1971094792 cites W2118531513 @default.
• W1971094792 cites W2133622312 @default.
• W1971094792 cites W2146509357 @default.
• W1971094792 cites W2162547415 @default.
• W1971094792 cites W2167548726 @default.
• W1971094792 cites W2397316750 @default.
• W1971094792 cites W2439008136 @default.
• W1971094792 cites W4244803411 @default.
• W1971094792 cites W4295333450 @default.
• W1971094792 cites W4313341523 @default.
• W1971094792 cites W48696652 @default.
• W1971094792 doi "https://doi.org/10.1016/s0969-9961(02)00008-6" @default.
• W1971094792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12609490" @default.
• W1971094792 hasPublicationYear "2003" @default.
• W1971094792 type Work @default.
• W1971094792 sameAs 1971094792 @default.
• W1971094792 citedByCount "102" @default.
• W1971094792 countsByYear W19710947922012 @default.
• W1971094792 countsByYear W19710947922013 @default.
• W1971094792 countsByYear W19710947922014 @default.
• W1971094792 countsByYear W19710947922015 @default.
• W1971094792 countsByYear W19710947922016 @default.
• W1971094792 countsByYear W19710947922017 @default.
• W1971094792 countsByYear W19710947922018 @default.
• W1971094792 countsByYear W19710947922019 @default.
• W1971094792 countsByYear W19710947922020 @default.
• W1971094792 countsByYear W19710947922021 @default.
• W1971094792 countsByYear W19710947922022 @default.
• W1971094792 countsByYear W19710947922023 @default.
• W1971094792 crossrefType "journal-article" @default.
• W1971094792 hasAuthorship W1971094792A5041874079 @default.
• W1971094792 hasAuthorship W1971094792A5043618169 @default.
• W1971094792 hasConcept C111684460 @default.
• W1971094792 hasConcept C159654299 @default.
• W1971094792 hasConcept C160448771 @default.
• W1971094792 hasConcept C169760540 @default.
• W1971094792 hasConcept C170493617 @default.
• W1971094792 hasConcept C171779818 @default.
• W1971094792 hasConcept C175773311 @default.
• W1971094792 hasConcept C185592680 @default.
• W1971094792 hasConcept C203014093 @default.
• W1971094792 hasConcept C2776914184 @default.
• W1971094792 hasConcept C2778163477 @default.
• W1971094792 hasConcept C2778609137 @default.
• W1971094792 hasConcept C2779830541 @default.
• W1971094792 hasConcept C2780072125 @default.
• W1971094792 hasConcept C41443022 @default.
• W1971094792 hasConcept C529278444 @default.
• W1971094792 hasConcept C55493867 @default.
• W1971094792 hasConcept C86803240 @default.
• W1971094792 hasConcept C95444343 @default.
• W1971094792 hasConceptScore W1971094792C111684460 @default.
• W1971094792 hasConceptScore W1971094792C159654299 @default.
• W1971094792 hasConceptScore W1971094792C160448771 @default.
• W1971094792 hasConceptScore W1971094792C169760540 @default.
• W1971094792 hasConceptScore W1971094792C170493617 @default.
• W1971094792 hasConceptScore W1971094792C171779818 @default.
• W1971094792 hasConceptScore W1971094792C175773311 @default.
• W1971094792 hasConceptScore W1971094792C185592680 @default.
• W1971094792 hasConceptScore W1971094792C203014093 @default.
• W1971094792 hasConceptScore W1971094792C2776914184 @default.
• W1971094792 hasConceptScore W1971094792C2778163477 @default.

• next