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- W1971094896 endingPage "975" @default.
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- W1971094896 abstract "The highly controlled interplay between MMPs and TIMPs is responsible for a constant turn-over of liver matrix and the maintenance of homeostasis and a healthy liver architecture. Acute liver injury may significantly disturb the susceptible equilibrium resulting in functional imbalance. In chronic liver injury, differently regulated MMP and TIMP expression leads to a positive feedback loop with subsequent fibrogenesis (an overview of the current knowledge with respect to expression profiles of MMPs and TIMPs in hepatic fibrosis is given in Fig. 3). Rat and mouse models demonstrated that complete reversibility of fibrosis might indeed be possible. Nevertheless, in human beings this seems to be much more complicated since susceptibility with respect to fibrosis is variable, and often toxic liver damage is ongoing. Therefore the induction of fibrolysis often fails and patients thus continue suffering from impaired liver function and eventually develop end-stage cirrhosis." @default.
- W1971094896 created "2016-06-24" @default.
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- W1971094896 creator A5009108182 @default.
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- W1971094896 creator A5075599540 @default.
- W1971094896 date "2007-05-01" @default.
- W1971094896 modified "2023-10-05" @default.
- W1971094896 title "Expression of MMPs and TIMPs in liver fibrosis – a systematic review with special emphasis on anti-fibrotic strategies" @default.
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